YNIMG Journal 2025 Journal Article
Reproducibility assessment of magnetic resonance spectroscopy of pregenual anterior cingulate cortex across sessions and vendors via the cloud computing platform CloudBrain-MRS
- Runhan Chen
- Meijin Lin
- Jianshu Chen
- Liangjie Lin
- Jiazheng Wang
- Xiaoqing Li
- Jianhua Wang
- Xu Huang
H-MRS scans without subject movement) on each machine. Absolute metabolite concentrations were analyzed for reliability of within- and between- session using the coefficient of variation (CV), intraclass correlation coefficient (ICC) and Bland-Altman (BA) plot, and for reproducibility across the machines using the Pearson correlation coefficient. As for within- and between- session, most of the CV values for a group of all the first or second scans of a session, and from each session were below 20 %, and most of ICCs ranged from moderate (0.4≤ICC<0.59) to excellent (ICC≥0.75), which indicated high reliability. Most of the BA plots had the line of equality between 95 % confidence interval of bias (mean difference), therefore the differences over scanning time could be negligible. Majority of the Pearson correlation coefficients approached 1 with statistical significance (P < 0.001), showing high reproducibility across the three scanners. Additionally, the intra-vendor reproducibility was greater than the inter-vendor ones.