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Jiale Zhou

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3 papers

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AAAI Conference 2026 Conference Paper

Multimodal Mixture-of-Experts with Retrieval Augmentation for Protein Active Site Identification

Jiayang Wu
Jiale Zhou
Rubo Wang
Xingyi Zhang
Xun Lin
Tianxu Lv
Leong Hou U
Yefeng Zheng

Accurate identification of protein active sites at the residue level is crucial for understanding protein function and advancing drug discovery. However, current methods face two critical challenges: vulnerability in single-instance prediction due to sparse training data, and inadequate modality reliability estimation that leads to performance degradation when unreliable modalities dominate fusion processes. To address these challenges, we introduce Multimodal Mixtureof-Experts with Retrieval Augmentation (MERA), the first retrieval-augmented framework for protein active site identification. MERA employs hierarchical multi-expert retrieval that dynamically aggregates contextual information from chain, sequence, and active-site perspectives through residuelevel mixture-of-experts gating. To prevent modality degradation, we propose a reliability-aware fusion strategy based on Dempster–Shafer evidence theory that quantifies modality trustworthiness through belief mass functions and learnable discounting coefficients, enabling principled multimodal integration. Extensive experiments on ProTAD-Gen and TS125 datasets demonstrate that MERA achieves state-of-the-art performance, with 90% AUPRC on active site prediction and significant gains on peptide-binding site identification, validating the effectiveness of retrieval-augmented multi-expert modeling and reliability-guided fusion

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AAAI Conference 2026 Conference Paper

StegaVAR: Privacy-Preserving Video Action Recognition via Steganographic Domain Analysis

Lixin Chen
Chaomeng Chen
Jiale Zhou
Zhijian Wu
Xun Lin

Despite the rapid progress of deep learning in video action recognition (VAR) in recent years, privacy leakage in videos remains a critical concern. Current state-of-the-art privacy-preserving methods often rely on anonymization. These methods suffer from (1) low concealment, where producing visually distorted videos that attract attackers’ attention during transmission, and (2) spatiotemporal disruption, where degrading essential spatiotemporal features for accurate VAR. To address these issues, we propose StegaVAR, a novel framework that embeds action videos into ordinary cover videos and directly performs VAR in the steganographic domain for the first time. Throughout both data transmission and action analysis, the spatiotemporal information of hidden secret video remains complete, while the natural appearance of cover videos ensures the concealment of transmission. Considering the difficulty of steganographic domain analysis, we propose Secret Spatio-Temporal Promotion (STeP) and Cross-Band Difference Attention (CroDA) for analysis within the steganographic domain. STeP uses the secret video to guide spatiotemporal feature extraction in the steganographic domain during training. CroDA suppresses cover interference by capturing cross-band semantic differences. Experiments demonstrate that StegaVAR achieves superior VAR and privacy-preserving performance on widely used datasets. Moreover, our framework is effective for multiple steganographic models.

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IJCAI Conference 2021 Conference Paper

Learning Implicit Temporal Alignment for Few-shot Video Classification

Songyang Zhang
Jiale Zhou
Xuming He

Few-shot video classification aims to learn new video categories with only a few labeled examples, alleviating the burden of costly annotation in real-world applications. However, it is particularly challenging to learn a class-invariant spatial-temporal representation in such a setting. To address this, we propose a novel matching-based few-shot learning strategy for video sequences in this work. Our main idea is to introduce an implicit temporal alignment for a video pair, capable of estimating the similarity between them in an accurate and robust manner. Moreover, we design an effective context encoding module to incorporate spatial and feature channel context, resulting in better modeling of intra-class variations. To train our model, we develop a multi-task loss for learning video matching, leading to video features with better generalization. Extensive experimental results on two challenging benchmarks, show that our method outperforms the prior arts with a sizable margin on Something-Something-V2 and competitive results on Kinetics.

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