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Jia Duan

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5 papers
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5

EAAI Journal 2026 Journal Article

A Center-Focused Transformer for hyperspectral image classification

  • Chaoxu Yang
  • Jia Duan
  • Xi Liu
  • Lianchong Zhang
  • Jiangbing Sun
  • Yan Zhang
  • Wei Ren

In recent years, transformer-based methods have achieved remarkable progress in hyperspectral image classification (HSIC). However, they often rely heavily on extensive training samples to achieve optimal performance. Moreover, these methods frequently fail to adequately capture diverse local spectral–spatial correlations and multi-granular features inherent in hyperspectral images (HSIs). Crucially, existing approaches often overlook the pivotal role of the target center pixel. Their attention mechanisms tend to focus on irrelevant background regions, thereby reducing feature discriminability and degrading classification accuracy. To address these challenges, we propose a novel Center-Focused Transformer (CFT) framework that seamlessly integrates multi-scale spectral–spatial fusion for HSIC. Our framework comprises three key components. First, the Spectral–Spatial Fusion (SSF) mechanism integrates local and global dependencies by employing PCA alongside a Superpixel Graph Feature Extraction (SGFE) block. Second, the Multi-Granular Feature Enhancement (MGFE) approach strengthens spectral–spatial interactions through patch augmentation, a HybridConv block, and a Multi-Scale CBAM (MS-CBAM) block. Finally, the Focus Center Transformer (FCT) strategy explicitly emphasizes the importance of the central pixel for precise classification by incorporating Gaussian Positional Embedding (GPE) and cross-layer aggregation. Extensive experiments on four public datasets demonstrate that the proposed CFT consistently outperforms state-of-the-art methods, highlighting its potential for practical engineering applications. • A novel Center-Focused Transformer (CFT) framework is proposed for hyperspectral image classification. • The CFT model integrates a Spectral–Spatial Fusion (SSF) mechanism to effectively capture local and global dependencies. • A Multi-Granular Feature Enhancement (MGFE) approach is introduced to model multi-scale features in both spectral and spatial dimensions. • A Focus Center Transformer (FCT) strategy with Gaussian positional embedding is proposed to improve classification accuracy. • The CFT consistently outperforms state-of-the-art methods on four public datasets, showcasing its potential for engineering applications.

YNICL Journal 2023 Journal Article

Predicting treatment response in adolescents and young adults with major depressive episodes from fMRI using graph isomorphism network

  • Jia Duan
  • Yueying Li
  • Xiaotong Zhang
  • Shuai Dong
  • Pengfei Zhao
  • Jie Liu
  • Junjie Zheng
  • Rongxin Zhu

BACKGROUND: Major depressive episode (MDE) is the main clinical feature of mood disorders (major depressive disorder and bipolar disorder) in adolescents and young adults and accounts for most of the disease course. However, 30%-40% of MDE patients not responding to clinical first-line interventions. It is crucial to predict treatment response in the early stages and identify biomarkers associated with treatment response. Graph Isomorphism Network (GIN), a deep learning method, is promising for predicting treatment response for individual MDE patients with more powerful representation ability to capture the features of brain functional connectivity. METHODS: In this study, GIN was used to predict individual treatment response in 198 adolescents and young adults with MDE. The most discriminating regions were also identified for the treatment response prediction. RESULTS: Using GIN approach, the baseline functional connectivity could predict 79.8% responders and 67.4% non-responders to treatment (accuracy 74.24%). Furthermore, the most discriminating brain regions were mainly involved in paralimbic and subcortical areas. CONCLUSIONS: GIN has shown potential in predicting treatment response for individual patients, which may enable personalized treatment decisions. Furthermore, targeted interventions focused on modulating the activity and connectivity within paralimbic and subcortical regions could potentially improve treatment outcomes and enable personalized interventions for adolescents and young adults with MDE.

AAAI Conference 2021 Conference Paper

Detecting Adversarial Examples from Sensitivity Inconsistency of Spatial-Transform Domain

  • Jinyu Tian
  • Jiantao Zhou
  • Yuanman Li
  • Jia Duan

Deep neural networks (DNNs) have been shown to be vulnerable against adversarial examples (AEs), which are maliciously designed to cause dramatic model output errors. In this work, we reveal that normal examples (NEs) are insensitive to the fluctuations occurring at the highly-curved region of the decision boundary, while AEs typically designed over one single domain (mostly spatial domain) exhibit exorbitant sensitivity on such fluctuations. This phenomenon motivates us to design another classifier (called dual classifier) with transformed decision boundary, which can be collaboratively used with the original classifier (called primal classifier) to detect AEs, by virtue of the sensitivity inconsistency. When comparing with the state-of-the-art algorithms based on Local Intrinsic Dimensionality (LID), Mahalanobis Distance (MD), and Feature Squeezing (FS), our proposed Sensitivity Inconsistency Detector (SID) achieves improved AE detection performance and superior generalization capabilities, especially in the challenging cases where the adversarial perturbation levels are small. Intensive experimental results on ResNet and VGG validate the superiority of the proposed SID.

YNICL Journal 2020 Journal Article

Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium

  • Yicheng Long
  • Hengyi Cao
  • Chaogan Yan
  • Xiao Chen
  • Le Li
  • Francisco Xavier Castellanos
  • Tongjian Bai
  • Qijing Bo

BACKGROUND: Major depressive disorder (MDD) is known to be characterized by altered brain functional connectivity (FC) patterns. However, whether and how the features of dynamic FC would change in patients with MDD are unclear. In this study, we aimed to characterize dynamic FC in MDD using a large multi-site sample and a novel dynamic network-based approach. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data were acquired from a total of 460 MDD patients and 473 healthy controls, as a part of the REST-meta-MDD consortium. Resting-state dynamic functional brain networks were constructed for each subject by a sliding-window approach. Multiple spatio-temporal features of dynamic brain networks, including temporal variability, temporal clustering and temporal efficiency, were then compared between patients and healthy subjects at both global and local levels. RESULTS: ). Corresponding local changes in MDD were mainly found in the default-mode, sensorimotor and subcortical areas. Measures of temporal variability and characteristic temporal path length were significantly correlated with depression severity in patients (corrected p < 0.05). Moreover, the observed between-group differences were robustly present in both first-episode, drug-naïve (FEDN) and non-FEDN patients. CONCLUSIONS: Our findings suggest that excessive temporal variations of brain FC, reflecting abnormal communications between large-scale bran networks over time, may underlie the neuropathology of MDD.

YNICL Journal 2020 Journal Article

Biotypes of major depressive disorder: Neuroimaging evidence from resting-state default mode network patterns

  • Sugai Liang
  • Wei Deng
  • Xiaojing Li
  • Andrew J. Greenshaw
  • Qiang Wang
  • Mingli Li
  • Xiaohong Ma
  • Tong-Jian Bai

BACKGROUND: Major depressive disorder (MDD) is heterogeneous disorder associated with aberrant functional connectivity within the default mode network (DMN). This study focused on data-driven identification and validation of potential DMN-pattern-based MDD subtypes to parse heterogeneity of the disorder. METHODS: The sample comprised 1397 participants including 690 patients with MDD and 707 healthy controls (HC) registered from multiple sites based on the REST-meta-MDD Project in China. Baseline resting-state functional magnetic resonance imaging (rs-fMRI) data was recorded for each participant. Discriminative features were selected from DMN between patients and HC. Patient subgroups were defined by K-means and principle component analysis in the multi-site datasets and validated in an independent single-site dataset. Statistical significance of resultant clustering were confirmed. Demographic and clinical variables were compared between identified patient subgroups. RESULTS: Two MDD subgroups with differing functional connectivity profiles of DMN were identified in the multi-site datasets, and relatively stable in different validation samples. The predominant dysfunctional connectivity profiles were detected among superior frontal cortex, ventral medial prefrontal cortex, posterior cingulate cortex and precuneus, whereas one subgroup exhibited increases of connectivity (hyperDMN MDD) and another subgroup showed decreases of connectivity (hypoDMN MDD). The hyperDMN subgroup in the discovery dataset had age-related severity of depressive symptoms. Patient subgroups had comparable demographic and clinical symptom variables. CONCLUSIONS: Findings suggest the existence of two neural subtypes of MDD associated with different dysfunctional DMN connectivity patterns, which may provide useful evidence for parsing heterogeneity of depression and be valuable to inform the search for personalized treatment strategies.