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Huisi Wu

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13 papers

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AAAI Conference 2026 Conference Paper

CiNuSeg: Class Incremental Nuclei Segmentation via Anchor-driven Consistency Learning with Dual Region Regularization

Xuexin Wu
Zhenhui Ding
Huisi Wu
Jing Qin

Recent advances in deep learning have led to significant improvements in nuclei segmentation from histological images, particularly when labels of all classes are available simultaneously during training. However, in clinical practice, real-world scenarios require a model to perform well in an incremental learning setting, where we anticipate the model to achieve satisfactory performance on previously unseen data while effectively mitigating catastrophic forgetting of old classes. Most previous methods alleviate forgetting by distilling old class knowledge through prototypes; however, they fail to adequately capture fine-grained details to address the challenge of high class similarity, which is particularly severe in histological images. To overcome these limitations, we propose a novel incremental learning method for nuclei segmentation (we call it CiNuSeg), which is composed of two key innovative modules. First, we propose a new Anchor-driven Consistency Learning (ACL) module to construct multi-level class anchors within each sample to effectively capture fine structural and textural details of nuclei, thereby significantly mitigating forgetting. Second, we develop a Dual Region Regularization (DRR) module to suppress new class representations within old class regions while enhancing new class representations within new class regions, strengthening the model's ability to discriminate between different nuclei types and improving inter-class separability. We further introduce an Adaptive Temperature Tuning (ATT) strategy to dynamically balance model stability and plasticity. Extensive experiments conducted on benchmarking MoNuSAC and CoNSeP pathological datasets demonstrate the effectiveness of our method, consistently achieving better performance than SOTAs in different settings. Codes will be available upon publication.

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AAAI Conference 2026 Conference Paper

Palimpsest: Reconciling the CISS Trilemma for Incremental Nuclei Segmentation

Jiajia Li
Huisi Wu

Adapting computational pathology models to evolving clinical diagnostics via Class-Incremental Semantic Segmentation (CISS) is critical. However, this task imposes a unique CISS Trilemma: a simultaneous failure to preserve the intricate tissue background (stability), distinguish morphologically similar new nuclei (plasticity), and maintain a constant model size (scalability), all under a strict exemplar-free constraint. To resolve this, we introduce Palimpsest, a novel framework that systematically decouples these conflicting demands. Palimpsest integrates three synergistic mechanisms: a Parameter-Conserving Synthesis (PCS) module merges lightweight adapters to ensure scalability; a novel Similarity-Aware Centroid Recalibration (SCR) module executes differentiated recalibration to counteract non-uniform foreground drift, securing plasticity; and an Adaptive Residual Shading (ARS) module performs logit-space decoupling to preserve background integrity, ensuring stability. Extensive experiments on two histopathology datasets demonstrate that Palimpsest significantly outperforms state-of-the-art methods, achieving a superior stability-plasticity balance, particularly in challenging long-term incremental scenarios.

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AAAI Conference 2026 Conference Paper

VPSentry: Semi-supervised Video Polyp Segmentation via Sentry-guided Long-term Prototype Fusion with Correlation Dynamic Propagation

Guilian Chen
Xiaoling Luo
Huisi Wu
Jing Qin

Automated polyp segmentation in colonoscopy videos is an essential computer-aided technology for early detection and removal of polyps. However, most existing video polyp segmentation methods are designed with pixel-level temporal learning mechanisms, at the cost of time-consuming frame-wise annotations. In this paper, we present VPSentry, a novel semi-supervised segmentation model with a sentry mechanism. Our model integrates a prototype memory to store the long-term spatiotemporal cues of colonoscopy videos. Moreover, we devise adaptive prototypes to capture and generalize critical representations from individual frames, enabling long-term temporal fusion across labeled and unlabeled frames. In addition, we propose a correlation dynamic propagation module that propagates information from prototypes to features while simultaneously extracting dynamic features to perceive variations in polyp details between adjacent frames. Since colonoscopy scenes may change among consecutive frames, we further employ a sentry mechanism to assess the inter-frame continuity. This mechanism guides the prototype memory updating and the correlation dynamic propagation, further facilitating robust temporal propagation and dynamic detail perception for semi-supervised learning of long-term colonoscopy video sequences. Extensive experiments on the large-scale SUN-SEG dataset demonstrate that our model achieves optimal segmentation performance with real-time inference efficiency.

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AAAI Conference 2025 Conference Paper

Like an Ophthalmologist: Dynamic Selection Driven Multi-View Learning for Diabetic Retinopathy Grading

Xiaoling Luo
Qihao Xu
Huisi Wu
Chengliang Liu
Zhihui Lai
Linlin Shen

Diabetic retinopathy (DR), with its large patient population, has become a formidable threat to human visual health. In the clinical diagnosis of DR, multi-view fundus images are considered to be more suitable for DR diagnosis because of the wide coverage of the field of view. Therefore, different from most of the previous single-view DR grading methods, we design a dynamic selection-driven multi-view DR grading method to fit clinical scenarios better. Since lesion information plays a key role in DR diagnosis, previous methods usually boost the model performance by enhancing the lesion feature. However, during the actual diagnosis, ophthalmologists not only focus on the crucial parts, but also exclude irrelevant features to ensure the accuracy of judgment. To this end, we introduce the idea of dynamic selection and design a series of selection mechanisms from fine granularity to coarse granularity. In this work, we first introduce an Ophthalmic Image Reader (OIR) agent to provide the model with pixel-level prompts of suspected lesion areas. Moreover, a Multi-View Token Selection Module (MVTSM) is designed to prune redundant feature tokens and realize dynamic selection of key information. In the final decision stage, we dynamically fuse multi-view features through the novel Multi-View Mixture of Experts Module (MVMoEM), to enhance key views and reduce the impact of conflicting views. Extensive experiments on a large multi-view fundus image dataset with 34,452 images demonstrate that our method performs favorably against state-of-the-art models.

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AAAI Conference 2024 Conference Paper

An Embedding-Unleashing Video Polyp Segmentation Framework via Region Linking and Scale Alignment

Zhixue Fang
Xinrong Guo
Jingyin Lin
Huisi Wu
Jing Qin

Automatic polyp segmentation from colonoscopy videos is a critical task for the development of computer-aided screening and diagnosis systems. However, accurate and real-time video polyp segmentation (VPS) is a very challenging task due to low contrast between background and polyps and frame-to-frame dramatic variations in colonoscopy videos. We propose a novel embedding-unleashing framework consisting of a proposal-generative network (PGN) and an appearance-embedding network (AEN) to comprehensively address these challenges. Our framework, for the first time, models VPS as an appearance-level semantic embedding process to facilitate generate more global information to counteract background disturbances and dramatic variations. Specifically, PGN is a video segmentation network to obtain segmentation mask proposals, while AEN is a network we specially designed to produce appearance-level embedding semantics for PGN, thereby unleashing the capability of PGN in VPS. Our AEN consists of a cross-scale region linking (CRL) module and a cross-wise scale alignment (CSA) module. The former screens reliable background information against background disturbances by constructing linking of region semantics, while the latter performs the scale alignment to resist dramatic variations by modeling the center-perceived motion dependence with a cross-wise manner. We further introduce a parameter-free semantic interaction to embed the semantics of AEN into PGN to obtain the segmentation results. Extensive experiments on CVC-612 and SUN-SEG demonstrate that our approach achieves better performance than other state-of-the-art methods. Codes are available at https://github.com/zhixue-fang/EUVPS.

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IJCAI Conference 2024 Conference Paper

CONC: Complex-noise-resistant Open-set Node Classification with Adaptive Noise Detection

Qin Zhang
Jiexin Lu
Xiaowei Li
Huisi Wu
Shirui Pan
Junyang Chen

As a popular task in graph learning, node classification seeks to assign labels to nodes, taking into account both their features and connections. However, an important challenge for its application in real-world scenarios is the presence of newly-emerged out-of-distribution samples and noisy samples, which affect the quality and robustness of learned classifiers. Out-of-distribution (OOD) samples are often found in both the training and testing phases. Such samples don’t belong to any known categories. These OOD samples are considered as outliers (OOD noise) when they appear during training, and are recognized as open-set samples during the testing. Meanwhile, in-distribution (IND) noisy data, i. e. , known class samples with wrong labels, are also prevalent and inevitably degrade a model’s performance. The challenge of open-set learning with complex IND and OOD noise remains largely unexplored, particularly when dealing with non-IID graph data. To address these challenges, this paper introduces a novel complex-noise-resistant open-set node classification approach, designed for open-set graph data containing both IND and OOD noisy nodes. Specifically, a trustworthiness learner is adopted to learn the trustworthiness rates of the feature and label for each node while a decoder and an open-set classifier are trained to reconstruct the structure of a node and to predict its category simultaneously with the guidance of node trustworthiness. The experimental results demonstrate the superiority of our method.

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NeurIPS Conference 2024 Conference Paper

EGonc : Energy-based Open-Set Node Classification with substitute Unknowns

Qin Zhang
Zelin Shi
Shirui Pan
Junyang Chen
Huisi Wu
Xiaojun Chen

Open-set Classification (OSC) is a critical requirement for safely deploying machine learning models in the open world, which aims to classify samples from known classes and reject samples from out-of-distribution (OOD). Existing methods exploit the feature space of trained network and attempt at estimating the uncertainty in the predictions. However, softmax-based neural networks are found to be overly confident in their predictions even on data they have never seen before andthe immense diversity of the OOD examples also makes such methods fragile. To this end, we follow the idea of estimating the underlying density of the training data to decide whether a given input is close to the in-distribution (IND) data and adopt Energy-based models (EBMs) as density estimators. A novel energy-based generative open-set node classification method, \textit{EGonc}, is proposed to achieve open-set graph learning. Specifically, we generate substitute unknowns to mimic the distribution of real open-set samples firstly, based on the information of graph structures. Then, an additional energy logit representing the virtual OOD class is learned from the residual of the feature against the principal space, and matched with the original logits by a constant scaling. This virtual logit serves as the indicator of OOD-ness. EGonc has nice theoretical properties that guarantee an overall distinguishable margin between the detection scores for IND and OOD samples. Comprehensive experimental evaluations of EGonc also demonstrate its superiority.

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AAAI Conference 2024 Conference Paper

FedCD: Federated Semi-Supervised Learning with Class Awareness Balance via Dual Teachers

Yuzhi Liu
Huisi Wu
Jing Qin

Recent advancements in deep learning have greatly improved the efficiency of auxiliary medical diagnostics. However, concerns over patient privacy and data annotation costs restrict the viability of centralized training models. In response, federated semi-supervised learning has garnered substantial attention from medical institutions. However, it faces challenges arising from knowledge discrepancies among local clients and class imbalance in non-independent and identically distributed data. Existing methods like class balance adaptation for addressing class imbalance often overlook low-confidence yet valuable rare samples in unlabeled data and may compromise client privacy. To address these issues, we propose a novel framework with class awareness balance and dual teacher distillation called FedCD. FedCD introduces a global-local framework to balance and purify global and local knowledge. Additionally, we introduce a novel class awareness balance module to effectively explore potential rare classes and encourage balanced learning in unlabeled clients. Importantly, our approach prioritizes privacy protection by only exchanging network parameters during communication. Experimental results on two medical datasets under various settings demonstrate the effectiveness of FedCD. The code is available at https://github.com/YunzZ-Liu/FedCD.

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AAAI Conference 2023 Conference Paper

ACL-Net: Semi-supervised Polyp Segmentation via Affinity Contrastive Learning

Huisi Wu
Wende Xie
Jingyin Lin
Xinrong Guo

Automatic polyp segmentation from colonoscopy images is an essential prerequisite for the development of computer-assisted therapy. However, the complex semantic information and the blurred edges of polyps make segmentation extremely difficult. In this paper, we propose a novel semi-supervised polyp segmentation framework using affinity contrastive learning (ACL-Net), which is implemented between student and teacher networks to consistently refine the pseudo-labels for semi-supervised polyp segmentation. By aligning the affinity maps between the two branches, a better polyp region activation can be obtained to fully exploit the appearance-level context encoded in the feature maps, thereby improving the capability of capturing not only global localization and shape context, but also the local textural and boundary details. By utilizing the rich inter-image affinity context and establishing a global affinity context based on the memory bank, a cross-image affinity aggregation (CAA) module is also implemented to further refine the affinity aggregation between the two branches. By continuously and adaptively refining pseudo-labels with optimized affinity, we can improve the semi-supervised polyp segmentation based on the mutually reinforced knowledge interaction among contrastive learning and consistency learning iterations. Extensive experiments on five benchmark datasets, including Kvasir-SEG, CVC-ClinicDB, CVC-300, CVC-ColonDB and ETIS, demonstrate the effectiveness and superiority of our method. Codes are available at https://github.com/xiewende/ACL-Net.

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AAAI Conference 2023 Conference Paper

Super-efficient Echocardiography Video Segmentation via Proxy- and Kernel-Based Semi-supervised Learning

Huisi Wu
Jingyin Lin
Wende Xie
Jing Qin

Automatic segmentation of left ventricular endocardium in echocardiography videos is critical for assessing various cardiac functions and improving the diagnosis of cardiac diseases. It is yet a challenging task due to heavy speckle noise, significant shape variability of cardiac structure, and limited labeled data. Particularly, the real-time demand in clinical practice makes this task even harder. In this paper, we propose a novel proxy- and kernel-based semi-supervised segmentation network (PKEcho-Net) to comprehensively address these challenges. We first propose a multi-scale region proxy (MRP) mechanism to model the region-wise contexts, in which a learnable region proxy with an arbitrary shape is developed in each layer of the encoder, allowing the network to identify homogeneous semantics and hence alleviate the influence of speckle noise on segmentation. To sufficiently and efficiently exploit temporal consistency, different from traditional methods which only utilize the temporal contexts of two neighboring frames via feature warping or self-attention mechanism, we formulate the semi-supervised segmentation with a group of learnable kernels, which can naturally and uniformly encode the appearances of left ventricular endocardium, as well as extracting the inter-frame contexts across the whole video to resist the fast shape variability of cardiac structures. Extensive experiments have been conducted on two famous public echocardiography video datasets, EchoNet-Dynamic and CAMUS. Our model achieves the best performance-efficiency trade-off when compared with other state-of-the-art approaches, attaining comparative accuracy with a much faster speed. The code is available at https://github.com/JingyinLin/PKEcho-Net.

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AAAI Conference 2021 Conference Paper

Deep Style Transfer for Line Drawings

Xueting Liu
Wenliang Wu
Huisi Wu
Zhenkun Wen

Line drawings are frequently used to illustrate ideas and concepts in digital documents and presentations. To compose a line drawing, it is common for users to retrieve multiple line drawings from the Internet and combine them as one image. However, different line drawings may have different line styles and are visually inconsistent when put together. In order that the line drawings can have consistent looks, in this paper, we make the first attempt to perform style transfer for line drawings. The key of our design lies in the fact that centerline plays a very important role in preserving line topology and extracting style features. With this finding, we propose to formulate the style transfer problem as a centerline stylization problem and solve it via a novel style-guided image-toimage translation network. Results and statistics show that our method significantly outperforms the existing methods both visually and quantitatively.

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AAAI Conference 2021 Conference Paper

Precise Yet Efficient Semantic Calibration and Refinement in ConvNets for Real-time Polyp Segmentation from Colonoscopy Videos

Huisi Wu
Jiafu Zhong
Wei Wang
Zhenkun Wen
Jing Qin

We propose a novel convolutional neural network (ConvNet) equipped with two new semantic calibration and refinement approaches for automatic polyp segmentation from colonoscopy videos. While ConvNets set state-of-the-are performance for this task, it is still difficult to achieve satisfactory results in a real-time manner, which is a necessity in clinical practice. The main obstacle is the huge semantic gap between high-level features and low-level features, making it difficult to take full advantage of complementary semantic information contained in these hierarchical features. Compared with existing solutions, which either directly aggregate these features without considering the semantic gap or employ sophisticated non-local modeling techniques to refine semantic information by introduce many extra computational costs, the proposed ConvNet is able to more precisely yet efficiently calibrate and refine semantic information for better segmentation performance without increasing model complexity; we call the proposed ConvNet as SCR-Net, which has two key modules. We first propose a semantic calibration module (SCM) to effectively transmit the semantic information from high-level layers to low-level layers by learning the semantic-spatial relations during the training procedure. We then propose a semantic refinement module (SRM) to, based on the features calibrated by SCM, enhance the discrimination capability of the features for targeting objects. Extensive experiments on the Kvasir-SEG dataset demonstrate that the proposed SCR-Net is capable of achieving better segmentation accuracy than state-of-the-art approaches with a faster speed. The proposed techniques are general enough to be applied to similar applications where precise and efficient multi-level feature fusion is critical. The code is available at https: //github. com/jiafuz/SCR-Net.

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AAAI Conference 2021 Conference Paper

Region-aware Global Context Modeling for Automatic Nerve Segmentation from Ultrasound Images

Huisi Wu
Jiasheng Liu
Wei Wang
Zhenkun Wen
Jing Qin

We present a novel deep learning model equipped with a new region-aware global context modeling technique for automatic nerve segmentation from ultrasound images, which is a challenging task due to (1) the large variation and blurred boundaries of targets, (2) the large amount of speckle noise in ultrasound images, and (3) the inherent real-time requirement of this task. It is essential to efficiently capture long-range dependencies by global context modeling for a segmentation network to overcome these challenges. Traditional global context modeling techniques usually explore pixel-aware correlations to establish long-range dependencies, which are usually computation-intensive and greatly degrade time performance. In addition, in this application, pixel-aware modeling may inevitably introduce much speckle noise in the computation and potentially degrade segmentation performance. In this paper, we propose a novel region-aware modeling technique to establish long-range dependencies based on different regions to improve segmentation accuracy while maintaining real-time performance; we call it region-aware pyramid aggregation (RPA) module. In order to adaptively divide the feature maps into a set of semantic-independent regions, we develop an attention mechanism and integrate it into the spatial pyramid network to evaluate the semantic similarity of different regions. We further develop an adaptive pyramid fusion (APF) module to dynamically fuse the multi-level features generated from the decoder to refining the segmentation results. We conducted extensive experiments on a famous public ultrasound nerve image segmentation dataset. Experimental results demonstrate that our method consistently outperforms our rivals in terms of segmentation accuracy. The code is available at https: //github. com/jsonliu-szu/RAGCM.

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