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Hui Xia

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3 papers
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3

AAAI Conference 2025 Conference Paper

Clean-Label Graph Backdoor Attack in the Node Classification Task

  • Hui Xia
  • Xiangwei Zhao
  • Rui Zhang
  • Shuo Xu
  • Luming Wang

Graph neural networks (GNNs) have achieved impressive results in various graph learning tasks. Backdoor attacks pose a significant threat to GNNs, with a focus on dirty-label attacks. However, these attacks often necessitate the inclusion of blatantly incorrect inputs into the training set, rendering them easily detectable through simple filtering. In response to this challenge, we introduce Clean-Label Graph Backdoor Attack (CGBA). The majority of features in the generated poisoned nodes align with their true labels, significantly enhancing the difficulty of detecting the attack. Firstly, leveraging the uncertainty inherent in the GNNs, we develop a low-budget strategy for selecting poisoned nodes. This approach focuses on nodes in the target class with uncertain and low-degree classifications, allowing for efficient attacks within a limited budget while mitigating the impact on other clean nodes. Secondly, we present an innovative strategy for generating feature triggers. By boosting the confidence of poisoned samples in the target class, this tactic establishes a robust association between the trigger and the target class, even without modifying the labels of poisoned nodes. Additionally, we incorporate two constraints to reduce disruption to the graph structure. In conclusion, comprehensive experimental results unequivocally showcase CGBA's exceptional attack performance across three benchmark datasets and four GNNs models. Notably, the attack targeting the GraphSAGE model attains a 100% success rate, accompanied by a marginal benign accuracy drop of no more than 0.5%.

JBHI Journal 2022 Journal Article

Investigating miRNA-mRNA Interactions and Gene Regulatory Networks From VTA Dopaminergic Neurons Following Perinatal Nicotine and Alcohol Exposure Using Bayesian Network Analysis

  • Hui Xia
  • Yasemin M. Akay
  • Metin Akay

MicroRNAs play an important role in gene regulation for many biological systems, including nicotine and alcohol addiction. However, the underlying mechanism behind miRNAs and mRNA interaction is not well characterized. Microarrays are commonly used to quantify the expression levels of mRNAs and/or miRNAs simultaneously. In this study, we performed a Bayesian network analysis to identify mRNA and miRNA interactions following perinatal exposure to nicotine and/or alcohol. We utilized three sets of microarray data to predict the regulation relationship between mRNA and miRNAs. Following perinatal alcohol exposure, we identified two miRNAs: miR-542-5p and miR-874-3p, that exhibited a strong mutual influence on several mRNA in gene regulatory pathways, mainly Axon guidance and Dopaminergic synapses. Finally, we confirmed our predicted addiction pathways based on the Bayesian network analysis with the widely used Kyoto Encyclopedia of Genes and Genomes (KEGG)-based database and identified comparable relevant miRNA-mRNA pairs. We believe the Bayesian network can provide insight into the complexity biological process related to addiction and can potentially be applied to other diseases.