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Haoxin Chen

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ICLR Conference 2024 Conference Paper

ScaleCrafter: Tuning-free Higher-Resolution Visual Generation with Diffusion Models

  • Yingqing He
  • Shaoshu Yang
  • Haoxin Chen
  • Xiaodong Cun
  • Menghan Xia
  • Yong Zhang 0034
  • Xintao Wang 0002
  • Ran He 0001

In this work, we investigate the capability of generating images from pre-trained diffusion models at much higher resolutions than the training image sizes. In addition, the generated images should have arbitrary image aspect ratios. When generating images directly at a higher resolution, 1024 x 1024, with the pre-trained Stable Diffusion using training images of resolution 512 x 512, we observe persistent problems of object repetition and unreasonable object structures. Existing works for higher-resolution generation, such as attention-based and joint-diffusion approaches, cannot well address these issues. As a new perspective, we examine the structural components of the U-Net in diffusion models and identify the crucial cause as the limited perception field of convolutional kernels. Based on this key observation, we propose a simple yet effective re-dilation that can dynamically adjust the convolutional perception field during inference. We further propose the dispersed convolution and noise-damped classifier-free guidance, which can enable ultra-high-resolution image generation (e.g., 4096 x 4096). Notably, our approach does not require any training or optimization. Extensive experiments demonstrate that our approach can address the repetition issue well and achieve state-of-the-art performance on higher-resolution image synthesis, especially in texture details. Our work also suggests that a pre-trained diffusion model trained on low-resolution images can be directly used for high-resolution visual generation without further tuning, which may provide insights for future research on ultra-high-resolution image and video synthesis. More results are available at the anonymous website: https://scalecrafter.github.io/ScaleCrafter/

YNICL Journal 2024 Journal Article

The association of motor reserve and clinical progression in Parkinson’s disease

  • Xueqin Bai
  • Shiwei Zhang
  • Qiuyue Li
  • Tao Guo
  • Xiaojun Guan
  • Andan Qian
  • Shuangli Chen
  • Ronghui Zhou

OBJECTIVE: To explore the association of motor reserve (MR) and clinical progression in Parkinson's disease. METHODS: This longitudinal study using data from the Parkinson's progression markers initiative. Patients with de novo PD who underwent dopamine transporter scans at baseline and finished at least five years clinical follow-up assessments (including motor, cognitive, and non-motor symptoms) were included. The individual MR of PD patients were estimated based on initial motor deficits and striatal dopamine depletion using a residual model. Linear mixed-effects models (LME) were performed to examine the associations of baseline MR and clinical progression. RESULTS: A total of 303 de novo PD patients were included and the mean follow-up time was 8.95 years. Results of LME models revealed that the baseline MR was associated with motor, cognitive, and non-motor symptoms in PD patients. There was a significant interaction between MR and disease duration for longitudinal changes in motor (p < 0.001), cognitive (p = 0.028) and depression symptoms (p = 0.014). PD patients with lower MR had a more rapid progression to postural instability and cognitive impairment compared with those with higher MR (p = 0.002 and p = 0.001, respectively). CONCLUSIONS: The baseline MR of PD patients were associated with motor and non-motor symptoms and can predicted disease prognosis, suggesting that the initial MR in PD would be associated with the individual's capacity to cope with neurodegenerative process as well as comprehensive prognosis.