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Fuxin Ren

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

5 papers

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YNIMG Journal 2025 Journal Article

Right inferior frontal cortex and preSMA in response inhibition: An investigation based on PTC model

Lili Wu
Mengjie Jiang
Min Zhao
Xin Hu
Jing Wang
Kaihua Zhang
Ke Jia
Fuxin Ren

Response inhibition is an essential component of cognitive function. A large body of literature has used neuroimaging data to uncover the neural architecture that regulates inhibitory control in general and movement cancelation. The presupplementary motor area (preSMA) and the right inferior frontal cortex (rIFC) are the key nodes in the inhibitory control network. However, how these two regions contribute to response inhibition remains controversial. Based on the Pause-then-Cancel Model (PTC), this study employed functional magnetic resonance imaging (fMRI) to investigate the functional specificity of two regions in the stopping process. The Go/No-Go task (GNGT) and the Stop Signal Task (SST) were administered to the same group of participants. We used the GNGT to dissociate the pause process and both the GNGT and the SST to investigate the inhibition mechanism. Imaging data revealed that response inhibition produced by both tasks activated the preSMA and rIFC. Furthermore, an across-participants analysis showed that increased activation in the rIFC was associated with a delay in the go response in the GNGT. In contrast, increased activation in the preSMA was associated with good inhibition efficiency via the striatum in both GNGT and SST. These behavioral and imaging findings support the PTC model of the role of rIFC and preSMA, that the former is involved in a pause process to delay motor responses, whereas the preSMA is involved in the stopping of motor responses.

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YNIMG Journal 2024 Journal Article

Brain extended and closed forms glutathione levels decrease with age and extended glutathione is associated with visuospatial memory

Xin Hu
Keyu Pan
Min Zhao
Jiali Lv
Jing Wang
Xiaofeng Zhang
Yuxi Liu
Yulu Song

During aging, the brain is subject to greater oxidative stress (OS), which is thought to play a critical role in cognitive impairment. Glutathione (GSH), as a major antioxidant in the brain, can be used to combat OS. However, how brain GSH levels vary with age and their associations with cognitive function is unclear. In this study, we combined point-resolved spectroscopy and edited spectroscopy sequences to investigate extended and closed forms GSH levels in the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and occipital cortex (OC) of 276 healthy participants (extended form, 166 females, age range 20-70 years) and 15 healthy participants (closed form, 7 females, age range 26-56 years), and examined their relationships with age and cognitive function. The results revealed decreased extended form GSH levels with age in the PCC among 276 participants. Notably, the timecourse of extended form GSH level changes in the PCC and ACC differed between males and females. Additionally, positive correlations were observed between extended form GSH levels in the PCC and OC and visuospatial memory. Additionally, a decreased trend of closed form GSH levels with age was also observed in the PCC among 15 participants. Taken together, these findings enhance our understanding of the brain both closed and extended form GSH time course during normal aging and associations with sex and memory, which is an essential first step for understanding the neurochemical underpinnings of healthy aging.

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YNIMG Journal 2023 Journal Article

Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis

Ning Li
Wen Ma
Fuxin Ren
Xiao Li
Fuyan Li
Wei Zong
Lili Wu
Zongrui Dai

Recent studies suggest that the interaction between presbycusis and cognitive impairment may be partially explained by the cognitive-ear link. However, the underlying neurophysiological mechanisms remain largely unknown. In this study, we combined magnetic resonance spectroscopy (MRS) and resting-state functional magnetic resonance imaging (fMRI) to investigate auditory gamma-aminobutyric acid (GABA) and glutamate (Glu) levels, intra- and inter-network functional connectivity, and their relationships with auditory and cognitive function in 51 presbycusis patients and 51 well-matched healthy controls. Our results confirmed reorganization of the cognitive-ear link in presbycusis, including decreased auditory GABA and Glu levels and aberrant functional connectivity involving auditory networks (AN) and cognitive-related networks, which were associated with reduced speech perception or cognitive impairment. Moreover, mediation analyses revealed that decreased auditory GABA levels and dysconnectivity between the AN and default mode network (DMN) mediated the association between hearing loss and impaired information processing speed in presbycusis. These findings highlight the importance of AN-DMN dysconnectivity in cognitive-ear link reorganization leading to cognitive impairment, and hearing loss may drive reorganization via decreased auditory GABA levels. Modulation of GABA neurotransmission may lead to new treatment strategies for cognitive impairment in presbycusis patients.

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IJCAI Conference 2020 Conference Paper

BANANA: when Behavior ANAlysis meets social Network Alignment

Fuxin Ren
Zhongbao Zhang
Jiawei Zhang
Sen Su
Li Sun
Guozhen Zhu
Congying Guo

Recently, aligning users among different social networks has received significant attention. However, most of the existing studies do not consider users’ behavior information during the aligning procedure and thus still suffer from the poor learning performance. In fact, we observe that social network alignment and behavior analysis can benefit from each other. Motivated by such an observation, we propose to jointly study the social network alignment problem and user behavior analysis problem. We design a novel end-to-end framework named BANANA. In this framework, to leverage behavior analysis for social network alignment at the distribution level, we design an earth mover’s distance based alignment model to fuse users’ behavior information for more comprehensive user representations. To further leverage social network alignment for behavior analysis, in turn, we design a temporal graph neural network model to fuse behavior information in different social networks based on the alignment result. Two models above can work together in an end-to-end manner. Through extensive experiments on real-world datasets, we demonstrate that our proposed approach outperforms the state-of-the-art methods in the social network alignment task and the user behavior analysis task, respectively.

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YNIMG Journal 2015 Journal Article

Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy

Fei Gao
Guangbin Wang
Wen Ma
Fuxin Ren
Muwei Li
Yuling Dong
Cheng Liu
Bo Liu

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central auditory system. Altered GABAergic neurotransmission has been found in both the inferior colliculus and the auditory cortex in animal models of presbycusis. Edited magnetic resonance spectroscopy (MRS), using the MEGA-PRESS sequence, is the most widely used technique for detecting GABA in the human brain. However, to date there has been a paucity of studies exploring changes to the GABA concentrations in the auditory region of patients with presbycusis. In this study, sixteen patients with presbycusis (5 males/11 females, mean age 63. 1±2. 6years) and twenty healthy controls (6 males/14 females, mean age 62. 5±2. 3years) underwent audiological and MRS examinations. Pure tone audiometry from 0. 125 to 8kHz and tympanometry were used to assess the hearing abilities of all subjects. The pure tone average (PTA; the average of hearing thresholds at 0. 5, 1, 2 and 4kHz) was calculated. The MEGA-PRESS sequence was used to measure GABA+ concentrations in 4×3×3cm3 volumes centered on the left and right Heschl's gyri. GABA+ concentrations were significantly lower in the presbycusis group compared to the control group (left auditory regions: p =0. 002, right auditory regions: p =0. 008). Significant negative correlations were observed between PTA and GABA+ concentrations in the presbycusis group (r =−0. 57, p =0. 02), while a similar trend was found in the control group (r =−0. 40, p =0. 08). These results are consistent with a hypothesis of dysfunctional GABAergic neurotransmission in the central auditory system in presbycusis and suggest a potential treatment target for presbycusis.

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