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Feng Huang

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14 papers
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14

AAAI Conference 2025 Conference Paper

LVPTrack: High Performance Domain Adaptive UAV Tracking with Label Aligned Visual Prompt Tuning

  • Hongjing Wu
  • Siyuan Yao
  • Feng Huang
  • Shu Wang
  • Linchao Zhang
  • Zhuoran Zheng
  • Wenqi Ren

Visual object tracking is essentially crucial for unmanned aerial vehicles (UAVs). Despite the substantial progress, most of the existing UAV trackers are designed for well-conditioned daytime data, while for the scenarios in challenging weather condition, e.g. foggy or nighttime environment, the tremendous domain gap leads to significant performance degradation. To address this issue, in this paper, we propose a novel robust UAV tracker termed LVPTrack, which conducts high quality label-aligned visual prompt tuning to adapt to various challenging weather conditions. Specifically, we first synthesize the sequential foggy and nighttime video frames to assist the model training. A domain adaptive teacher-student network is utilized to distill the hierarchical visual semantic of the target objects in cross-domain scenarios. Then we propose a target-aware pseudo-label voting (PLV) strategy to alleviate the target-level misalignment in the dual domains. Furthermore, we propose a dynamic aggregated prompt (DAP) module to facilitate the appearance variation adaptation of the target object in challenging scenarios. Extensive experiments demonstrate that our tracker achieves superior performance over existing state-of-the-art UAV trackers.

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AAAI Conference 2025 Conference Paper

RAP-SR: RestorAtion Prior Enhancement in Diffusion Models for Realistic Image Super-Resolution

  • Jiangang Wang
  • Qingnan Fan
  • Jinwei Chen
  • Hong Gu
  • Feng Huang
  • Wenqi Ren

Benefiting from their powerful generative capabilities, pretrained diffusion models have garnered significant attention for real-world image super-resolution (Real-SR). Existing diffusion-based SR approaches typically utilize semantic information from degraded images and restoration prompts to activate prior for producing realistic high-resolution images. However, general-purpose pretrained diffusion models, not designed for restoration tasks, often have suboptimal prior, and manually defined prompts may fail to fully exploit the generated potential. To address these limitations, we introduce RAP-SR, a novel restoration prior enhancement approach in pretrained diffusion models for Real-SR. First, we develop the High-Fidelity Aesthetic Image Dataset (HFAID), curated through a Quality-Driven Aesthetic Image Selection Pipeline (QDAISP). Our dataset not only surpasses existing ones in fidelity but also excels in aesthetic quality. Second, we propose the Restoration Priors Enhancement Framework, which includes Restoration Priors Refinement (RPR) and Restoration-Oriented Prompt Optimization (ROPO) modules. RPR refines the restoration prior using the HFAID, while ROPO optimizes the unique restoration identifier, improving the quality of the resulting images. RAP-SR effectively bridges the gap between general-purpose models and the demands of Real-SR by enhancing restoration prior. Leveraging the plug-and-play nature of RAP-SR, our approach can be seamlessly integrated into existing diffusion-based SR methods, boosting their performance. Extensive experiments demonstrate its broad applicability and state-of-the-art results.

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AAAI Conference 2024 Conference Paper

A Multi-Modal Contrastive Diffusion Model for Therapeutic Peptide Generation

  • Yongkang Wang
  • Xuan Liu
  • Feng Huang
  • Zhankun Xiong
  • Wen Zhang

Therapeutic peptides represent a unique class of pharmaceutical agents crucial for the treatment of human diseases. Recently, deep generative models have exhibited remarkable potential for generating therapeutic peptides, but they only utilize sequence or structure information alone, which hinders the performance in generation. In this study, we propose a Multi-Modal Contrastive Diffusion model (MMCD), fusing both sequence and structure modalities in a diffusion framework to co-generate novel peptide sequences and structures. Specifically, MMCD constructs the sequence-modal and structure-modal diffusion models, respectively, and devises a multi-modal contrastive learning strategy with inter-contrastive and intra-contrastive in each diffusion timestep, aiming to capture the consistency between two modalities and boost model performance. The inter-contrastive aligns sequences and structures of peptides by maximizing the agreement of their embeddings, while the intra-contrastive differentiates therapeutic and non-therapeutic peptides by maximizing the disagreement of their sequence/structure embeddings simultaneously. The extensive experiments demonstrate that MMCD performs better than other state-of-the-art deep generative methods in generating therapeutic peptides across various metrics, including antimicrobial/anticancer score, diversity, and peptide-docking.

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IJCAI Conference 2024 Conference Paper

Heterogeneous Causal Metapath Graph Neural Network for Gene-Microbe-Disease Association Prediction

  • Kexin Zhang
  • Feng Huang
  • Luotao Liu
  • Zhankun Xiong
  • Hongyu Zhang
  • Yuan Quan
  • Wen Zhang

The recent focus on microbes in human medicine highlights their potential role in the genetic framework of diseases. To decode the complex interactions among genes, microbes, and diseases, computational predictions of gene-microbe-disease (GMD) associations are crucial. Existing methods primarily address gene-disease and microbe-disease associations, but the more intricate triple-wise GMD associations remain less explored. In this paper, we propose a Heterogeneous Causal Metapath Graph Neural Network (HCMGNN) to predict GMD associations. HCMGNN constructs a heterogeneous graph linking genes, microbes, and diseases through their pairwise associations, and utilizes six predefined causal metapaths to extract directed causal subgraphs, which facilitate the multi-view analysis of causal relations among three entity types. Within each subgraph, we employ a causal semantic sharing message passing network for node representation learning, coupled with an attentive fusion method to integrate these representations for predicting GMD associations. Our extensive experiments show that HCMGNN effectively predicts GMD associations and addresses association sparsity issue by enhancing the graph's semantics and structure.

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IJCAI Conference 2024 Conference Paper

ZeroDDI: A Zero-Shot Drug-Drug Interaction Event Prediction Method with Semantic Enhanced Learning and Dual-modal Uniform Alignment

  • Ziyan Wang
  • Zhankun Xiong
  • Feng Huang
  • Xuan Liu
  • Wen Zhang

Drug-drug interactions (DDIs) can result in various pharmacological changes, which can be categorized into different classes known as DDI events (DDIEs). In recent years, previously unobserved/unseen DDIEs have been emerging, posing a new classification task when unseen classes have no labelled instances in the training stage, which is formulated as a zero-shot DDIE prediction (ZS-DDIE) task. However, existing computational methods are not directly applicable to ZS-DDIE, which has two primary challenges: obtaining suitable DDIE representations and handling the class imbalance issue. To overcome these challenges, we propose a novel method named ZeroDDI for the ZS-DDIE task. Specifically, we design a biological semantic enhanced DDIE representation learning module, which emphasizes the key biological semantics and distills discriminative molecular substructure-related semantics for DDIE representation learning. Furthermore, we propose a dual-modal uniform alignment strategy to distribute drug pair representations and DDIE semantic representations uniformly in unit sphere and align the matched ones, which can mitigate the issue of class imbalance. Extensive experiments showed that ZeroDDI surpasses the baselines and indicate that it is a promising tool for detecting unseen DDIEs. Our code has been released in https: //github. com/wzy-Sarah/ZeroDDI.

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AAAI Conference 2023 Conference Paper

Multi-Relational Contrastive Learning Graph Neural Network for Drug-Drug Interaction Event Prediction

  • Zhankun Xiong
  • Shichao Liu
  • Feng Huang
  • Ziyan Wang
  • Xuan Liu
  • Zhongfei Zhang
  • Wen Zhang

Drug-drug interactions (DDIs) could lead to various unexpected adverse consequences, so-called DDI events. Predicting DDI events can reduce the potential risk of combinatorial therapy and improve the safety of medication use, and has attracted much attention in the deep learning community. Recently, graph neural network (GNN)-based models have aroused broad interest and achieved satisfactory results in the DDI event prediction. Most existing GNN-based models ignore either drug structural information or drug interactive information, but both aspects of information are important for DDI event prediction. Furthermore, accurately predicting rare DDI events is hindered by their inadequate labeled instances. In this paper, we propose a new method, Multi-Relational Contrastive learning Graph Neural Network, MRCGNN for brevity, to predict DDI events. Specifically, MRCGNN integrates the two aspects of information by deploying a GNN on the multi-relational DDI event graph attributed with the drug features extracted from drug molecular graphs. Moreover, we implement a multi-relational graph contrastive learning with a designed dual-view negative counterpart augmentation strategy, to capture implicit information about rare DDI events. Extensive experiments on two datasets show that MRCGNN outperforms the state-of-the-art methods. Besides, we observe that MRCGNN achieves satisfactory performance when predicting rare DDI events.

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IJCAI Conference 2023 Conference Paper

Multi-view Contrastive Learning Hypergraph Neural Network for Drug-Microbe-Disease Association Prediction

  • Luotao Liu
  • Feng Huang
  • Xuan Liu
  • Zhankun Xiong
  • Menglu Li
  • Congzhi Song
  • Wen Zhang

Identifying the potential associations among drugs, microbes and diseases is of great significance in exploring the pathogenesis and improving precision medicine. There are plenty of computational methods for pair-wise association prediction, such as drug-microbe and microbe-disease associations, but few methods focus on the higher-order triple-wise drug-microbe-disease (DMD) associations. Driven by the advancement of hypergraph neural networks (HGNNs), we expect them to fully capture high-order interaction patterns behind the hypergraph formulated by DMD associations and realize sound prediction performance. However, the confirmed DMD associations are insufficient due to the high cost of in vitro screening, which forms a sparse DMD hypergraph and thus brings in suboptimal generalization ability. To mitigate the limitation, we propose a Multi-view Contrastive Learning Hypergraph Neural Network, named MCHNN, for DMD association prediction. We design a novel multi-view contrastive learning on the DMD hypergraph as an auxiliary task, which guides the HGNN to learn more discriminative representations and enhances the generalization ability. Extensive computational experiments show that MCHNN achieves satisfactory performance in DMD association prediction and, more importantly, demonstrate the effectiveness of our devised multi-view contrastive learning on the sparse DMD hypergraph.

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IJCAI Conference 2021 Conference Paper

CSGNN: Contrastive Self-Supervised Graph Neural Network for Molecular Interaction Prediction

  • Chengshuai Zhao
  • Shuai Liu
  • Feng Huang
  • Shichao Liu
  • Wen Zhang

Molecular interactions are significant resources for analyzing sophisticated biological systems. Identification of multifarious molecular interactions attracts increasing attention in biomedicine, bioinformatics, and human healthcare communities. Recently, a plethora of methods have been proposed to reveal molecular interactions in one specific domain. However, existing methods heavily rely on features or structures involving molecules, which limits the capacity of transferring the models to other tasks. Therefore, generalized models for the multifarious molecular interaction prediction (MIP) are in demand. In this paper, we propose a contrastive self-supervised graph neural network (CSGNN) to predict molecular interactions. CSGNN injects a mix-hop neighborhood aggregator into a graph neural network (GNN) to capture high-order dependency in the molecular interaction networks and leverages a contrastive self-supervised learning task as a regularizer within a multi-task learning paradigm to enhance the generalization ability. Experiments on seven molecular interaction networks show that CSGNN outperforms classic and state-of-the-art models. Comprehensive experiments indicate that the mix-hop aggregator and the self-supervised regularizer can effectively facilitate the link inference in multifarious molecular networks.

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