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Dufan Wu

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NeurIPS Conference 2025 Conference Paper

System-Embedded Diffusion Bridge Models

  • Bartlomiej Sobieski
  • Matthew Tivnan
  • Yuang Wang
  • Siyeop yoon
  • Pengfei Jin
  • Dufan Wu
  • Quanzheng Li
  • Przemyslaw Biecek

Solving inverse problems—recovering signals from incomplete or noisy measurements—is fundamental in science and engineering. Score-based generative models (SGMs) have recently emerged as a powerful framework for this task. Two main paradigms have formed: unsupervised approaches that adapt pretrained generative models to inverse problems, and supervised bridge methods that train stochastic processes conditioned on paired clean and corrupted data. While the former typically assume knowledge of the measurement model, the latter have largely overlooked this structural information. We introduce System-embedded Diffusion Bridge Models (SDBs), a new class of supervised bridge methods that explicitly embed the known linear measurement system into the coefficients of a matrix-valued SDE. This principled integration yields consistent improvements across diverse linear inverse problems and demonstrates robust generalization under system misspecification between training and deployment, offering a promising solution to real-world applications.

JBHI Journal 2020 Journal Article

Severity and Consolidation Quantification of COVID-19 From CT Images Using Deep Learning Based on Hybrid Weak Labels

  • Dufan Wu
  • Kuang Gong
  • Chiara Daniela Arru
  • Fatemeh Homayounieh
  • Bernardo Bizzo
  • Varun Buch
  • Hui Ren
  • Kyungsang Kim

Early and accurate diagnosis of Coronavirus disease (COVID-19) is essential for patient isolation and contact tracing so that the spread of infection can be limited. Computed tomography (CT) can provide important information in COVID-19, especially for patients with moderate to severe disease as well as those with worsening cardiopulmonary status. As an automatic tool, deep learning methods can be utilized to perform semantic segmentation of affected lung regions, which is important to establish disease severity and prognosis prediction. Both the extent and type of pulmonary opacities help assess disease severity. However, manually pixel-level multi-class labelling is time-consuming, subjective, and non-quantitative. In this article, we proposed a hybrid weak label-based deep learning method that utilize both the manually annotated pulmonary opacities from COVID-19 pneumonia and the patient-level disease-type information available from the clinical report. A UNet was firstly trained with semantic labels to segment the total infected region. It was used to initialize another UNet, which was trained to segment the consolidations with patient-level information using the Expectation-Maximization (EM) algorithm. To demonstrate the performance of the proposed method, multi-institutional CT datasets from Iran, Italy, South Korea, and the United States were utilized. Results show that our proposed method can predict the infected regions as well as the consolidation regions with good correlation to human annotation.

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