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Daniel Moyer

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9 papers
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9

NeurIPS Conference 2024 Conference Paper

NeuroBOLT: Resting-state EEG-to-fMRI Synthesis with Multi-dimensional Feature Mapping

  • Yamin Li
  • Ange Lou
  • Ziyuan Xu
  • Shengchao Zhang
  • Shiyu Wang
  • Dario J. Englot
  • Soheil Kolouri
  • Daniel Moyer

Functional magnetic resonance imaging (fMRI) is an indispensable tool in modern neuroscience, providing a non-invasive window into whole-brain dynamics at millimeter-scale spatial resolution. However, fMRI is constrained by issues such as high operation costs and immobility. With the rapid advancements in cross-modality synthesis and brain decoding, the use of deep neural networks has emerged as a promising solution for inferring whole-brain, high-resolution fMRI features directly from electroencephalography (EEG), a more widely accessible and portable neuroimaging modality. Nonetheless, the complex projection from neural activity to fMRI hemodynamic responses and the spatial ambiguity of EEG pose substantial challenges both in modeling and interpretability. Relatively few studies to date have developed approaches for EEG-fMRI translation, and although they have made significant strides, the inference of fMRI signals in a given study has been limited to a small set of brain areas and to a single condition (i. e. , either resting-state or a specific task). The capability to predict fMRI signals in other brain areas, as well as to generalize across conditions, remain critical gaps in the field. To tackle these challenges, we introduce a novel and generalizable framework: NeuroBOLT, i. e. , Neuro-to-BOLD Transformer, which leverages multi-dimensional representation learning from temporal, spatial, and spectral domains to translate raw EEG data to the corresponding fMRI activity signals across the brain. Our experiments demonstrate that NeuroBOLT effectively reconstructs unseen resting-state fMRI signals from primary sensory, high-level cognitive areas, and deep subcortical brain regions, achieving state-of-the-art accuracy with the potential to generalize across varying conditions and sites, which significantly advances the integration of these two modalities.

ECAI Conference 2024 Conference Paper

Sanitizing Hidden Information with Diffusion Models

  • Preston K. Robinette
  • Daniel Moyer
  • Taylor T. Johnson

Information hiding is the process of embedding data within another form of data, often to conceal its existence or prevent unauthorized access. This process is commonly used in various forms of secure communications (steganography) that can be used by bad actors to propagate malware, exfiltrate victim data, and discreetly communicate. Recent work has utilized deep neural networks to remove this hidden information in a defense mechanism known as sanitization. Previous deep learning works, however, are unable to scale efficiently beyond the MNIST dataset. In this work, we present a novel sanitization method called DM-SUDS that utilizes a diffusion model framework to sanitize/remove hidden information from image-into-image universal and dependent steganography from CIFAR-10 and ImageNet datasets. We evaluate DM-SUDS against three different baselines using MSE, PSNR, SSIM, and NCC metrics and provide further detailed analysis through an ablation study. DM-SUDS outperforms all three baselines and significantly improves image preservation MSE by 50. 44%, PSNR by 12. 69%, SSIM by 11. 49%, and NCC by 3. 26% compared to previous deep learning approaches. Additionally, we introduce a novel evaluation specification that considers the successful removal of hidden information (safety) as well as the resulting quality of the sanitized image (utility). We further demonstrate the versatility of this method with an application in an audio case study, demonstrating its broad applicability to additional domains.

NeurIPS Conference 2023 Conference Paper

NeuroGraph: Benchmarks for Graph Machine Learning in Brain Connectomics

  • Anwar Said
  • Roza Bayrak
  • Tyler Derr
  • Mudassir Shabbir
  • Daniel Moyer
  • Catie Chang
  • Xenofon Koutsoukos

Machine learning provides a valuable tool for analyzing high-dimensional functional neuroimaging data, and is proving effective in predicting various neurological conditions, psychiatric disorders, and cognitive patterns. In functional magnetic resonance imaging (MRI) research, interactions between brain regions are commonly modeled using graph-based representations. The potency of graph machine learning methods has been established across myriad domains, marking a transformative step in data interpretation and predictive modeling. Yet, despite their promise, the transposition of these techniques to the neuroimaging domain has been challenging due to the expansive number of potential preprocessing pipelines and the large parameter search space for graph-based dataset construction. In this paper, we introduce NeuroGraph, a collection of graph-based neuroimaging datasets, and demonstrated its utility for predicting multiple categories of behavioral and cognitive traits. We delve deeply into the dataset generation search space by crafting 35 datasets that encompass static and dynamic brain connectivity, running in excess of 15 baseline methods for benchmarking. Additionally, we provide generic frameworks for learning on both static and dynamic graphs. Our extensive experiments lead to several key observations. Notably, using correlation vectors as node features, incorporating larger number of regions of interest, and employing sparser graphs lead to improved performance. To foster further advancements in graph-based data driven neuroimaging analysis, we offer a comprehensive open-source Python package that includes the benchmark datasets, baseline implementations, model training, and standard evaluation.

ECAI Conference 2023 Conference Paper

SUDS: Sanitizing Universal and Dependent Steganography

  • Preston K. Robinette
  • Hanchen D. Wang
  • Nishan Shehadeh
  • Daniel Moyer
  • Taylor T. Johnson

Steganography, or hiding messages in plain sight, is a form of information hiding that is most commonly used for covert communication. As modern steganographic mediums include images, text, audio, and video, this communication method is being increasingly used by bad actors to propagate malware, exfiltrate data, and discreetly communicate. Current protection mechanisms rely upon steganalysis, or the detection of steganography, but these approaches are dependent upon prior knowledge, such as steganographic signatures from publicly available tools and statistical knowledge about known hiding methods. These dependencies render steganalysis useless against new or unique hiding methods, which are becoming increasingly common with the application of deep learning models. To mitigate the shortcomings of steganalysis, this work focuses on a deep learning sanitization technique called SUDS that is not reliant upon knowledge of steganographic hiding techniques and is able to sanitize universal and dependent steganography. SUDS is tested using least significant bit method (LSB), dependent deep hiding (DDH), and universal deep hiding (UDH). We demonstrate the capabilities and limitations of SUDS by answering five research questions, including baseline comparisons and an ablation study. Additionally, we apply SUDS to a real-world scenario, where it is able to increase the resistance of a poisoned classifier against attacks by 1375%.

YNIMG Journal 2020 Journal Article

Cross-scanner and cross-protocol multi-shell diffusion MRI data harmonization: Algorithms and results

  • Lipeng Ning
  • Elisenda Bonet-Carne
  • Francesco Grussu
  • Farshid Sepehrband
  • Enrico Kaden
  • Jelle Veraart
  • Stefano B. Blumberg
  • Can Son Khoo

Cross-scanner and cross-protocol variability of diffusion magnetic resonance imaging (dMRI) data are known to be major obstacles in multi-site clinical studies since they limit the ability to aggregate dMRI data and derived measures. Computational algorithms that harmonize the data and minimize such variability are critical to reliably combine datasets acquired from different scanners and/or protocols, thus improving the statistical power and sensitivity of multi-site studies. Different computational approaches have been proposed to harmonize diffusion MRI data or remove scanner-specific differences. To date, these methods have mostly been developed for or evaluated on single b-value diffusion MRI data. In this work, we present the evaluation results of 19 algorithms that are developed to harmonize the cross-scanner and cross-protocol variability of multi-shell diffusion MRI using a benchmark database. The proposed algorithms rely on various signal representation approaches and computational tools, such as rotational invariant spherical harmonics, deep neural networks and hybrid biophysical and statistical approaches. The benchmark database consists of data acquired from the same subjects on two scanners with different maximum gradient strength (80 and 300 ​mT/m) and with two protocols. We evaluated the performance of these algorithms for mapping multi-shell diffusion MRI data across scanners and across protocols using several state-of-the-art imaging measures. The results show that data harmonization algorithms can reduce the cross-scanner and cross-protocol variabilities to a similar level as scan-rescan variability using the same scanner and protocol. In particular, the LinearRISH algorithm based on adaptive linear mapping of rotational invariant spherical harmonics features yields the lowest variability for our data in predicting the fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK) and the rotationally invariant spherical harmonic (RISH) features. But other algorithms, such as DIAMOND, SHResNet, DIQT, CMResNet show further improvement in harmonizing the return-to-origin probability (RTOP). The performance of different approaches provides useful guidelines on data harmonization in future multi-site studies.

AAAI Conference 2020 Conference Paper

Invariant Representations through Adversarial Forgetting

  • Ayush Jaiswal
  • Daniel Moyer
  • Greg Ver Steeg
  • Wael AbdAlmageed
  • Premkumar Natarajan

We propose a novel approach to achieving invariance for deep neural networks in the form of inducing amnesia to unwanted factors of data through a new adversarial forgetting mechanism. We show that the forgetting mechanism serves as an information-bottleneck, which is manipulated by the adversarial training to learn invariance to unwanted factors. Empirical results show that the proposed framework achieves stateof-the-art performance at learning invariance in both nuisance and bias settings on a diverse collection of datasets and tasks.

NeurIPS Conference 2019 Conference Paper

Exact Rate-Distortion in Autoencoders via Echo Noise

  • Rob Brekelmans
  • Daniel Moyer
  • Aram Galstyan
  • Greg Ver Steeg

Compression is at the heart of effective representation learning. However, lossy compression is typically achieved through simple parametric models like Gaussian noise to preserve analytic tractability, and the limitations this imposes on learning are largely unexplored. Further, the Gaussian prior assumptions in models such as variational autoencoders (VAEs) provide only an upper bound on the compression rate in general. We introduce a new noise channel, Echo noise, that admits a simple, exact expression for mutual information for arbitrary input distributions. The noise is constructed in a data-driven fashion that does not require restrictive distributional assumptions. With its complex encoding mechanism and exact rate regularization, Echo leads to improved bounds on log-likelihood and dominates beta-VAEs across the achievable range of rate-distortion trade-offs. Further, we show that Echo noise can outperform flow-based methods without the need to train additional distributional transformations.

NeurIPS Conference 2019 Conference Paper

Fast structure learning with modular regularization

  • Greg Ver Steeg
  • Hrayr Harutyunyan
  • Daniel Moyer
  • Aram Galstyan

Estimating graphical model structure from high-dimensional and undersampled data is a fundamental problem in many scientific fields. Existing approaches, such as GLASSO, latent variable GLASSO, and latent tree models, suffer from high computational complexity and may impose unrealistic sparsity priors in some cases. We introduce a novel method that leverages a newly discovered connection between information-theoretic measures and structured latent factor models to derive an optimization objective which encourages modular structures where each observed variable has a single latent parent. The proposed method has linear stepwise computational complexity w. r. t. the number of observed variables. Our experiments on synthetic data demonstrate that our approach is the only method that recovers modular structure better as the dimensionality increases. We also use our approach for estimating covariance structure for a number of real-world datasets and show that it consistently outperforms state-of-the-art estimators at a fraction of the computational cost. Finally, we apply the proposed method to high-resolution fMRI data (with more than 10^5 voxels) and show that it is capable of extracting meaningful patterns.

NeurIPS Conference 2018 Conference Paper

Invariant Representations without Adversarial Training

  • Daniel Moyer
  • Shuyang Gao
  • Rob Brekelmans
  • Aram Galstyan
  • Greg Ver Steeg

Representations of data that are invariant to changes in specified factors are useful for a wide range of problems: removing potential biases in prediction problems, controlling the effects of covariates, and disentangling meaningful factors of variation. Unfortunately, learning representations that exhibit invariance to arbitrary nuisance factors yet remain useful for other tasks is challenging. Existing approaches cast the trade-off between task performance and invariance in an adversarial way, using an iterative minimax optimization. We show that adversarial training is unnecessary and sometimes counter-productive; we instead cast invariant representation learning as a single information-theoretic objective that can be directly optimized. We demonstrate that this approach matches or exceeds performance of state-of-the-art adversarial approaches for learning fair representations and for generative modeling with controllable transformations.

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