TCS Journal 2024 Journal Article
New approximation algorithms for RNA secondary structures prediction problems by local search
- Aizhong Zhou
- Haodi Feng
- Jiong Guo
- Haitao Jiang
- Nan Liu
- Binhai Zhu
- Daming Zhu
This paper investigates two combinatorial problems from RNA secondary structure prediction with arbitrary pseudoknots. Given a RNA sequence and a set of base pairs, two parallel and adjacent base pairs constitute a stacking. The Maximum Stacking Base Pairs problem (MSBP) aims at finding a maximum number of based pairs, all of which form stackings, while the Maximum Base Pair Stackings problem (MBPS) is to find a maximum number of stackings. Both problems are NP-hard. We present two new approximation algorithms for the two problems by local search methods. For MSBP, the approximation factor is improved from 5 2 to 7 3; as for the MBPS, the approximation factor is improved from 8 3 to 5 2.