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Dajiang Lei

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3 papers

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AAAI Conference 2026 Conference Paper

LungNoduleAgent: A Collaborative Multi-Agent System for Precision Diagnosis of Lung Nodules

Cheng Yang
Hui Jin
Xinlei Yu
Zhipeng Wang
Yaoqun Liu
Fenglei Fan
Dajiang Lei
Gangyong Jia

Diagnosing lung cancer typically involves physicians identifying lung nodules in Computed tomography (CT) scans and generating diagnostic reports based on their morphological features and medical expertise. Although advancements have been made in using multimodal large language models for analyzing lung CT scans, challenges remain in accurately describing nodule morphology and incorporating medical expertise. These limitations affect the reliability and effectiveness of these models in clinical settings. Collaborative multi-agent systems offer a promising strategy for achieving a balance between generality and precision in medical applications, yet their potential in pathology has not been thoroughly explored. To bridge these gaps, we introduce LungNoduleAgent, an innovative collaborative multi-agent system specifically designed for analyzing lung CT scans. LungNoduleAgent streamlines the diagnostic process into sequential components, improving precision in describing nodules and grading malignancy through three primary modules. The first module, the Nodule Spotter, coordinates clinical detection models to accurately identify nodules. The second module, the Radiologist, integrates localized image description techniques to produce comprehensive CT reports. Finally, the Doctor Agent System performs malignancy reasoning by using images and CT reports, supported by a pathology knowledge base and a multi-agent system framework. Extensive testing on two private datasets and the public LIDC-IDRI dataset indicates that LungNoduleAgent surpasses mainstream vision-language models, agent systems, and advanced expert models such as GPT-4o, Claude 3.7 Sonnet, LLaMA-3.2 Vision, Qwen2.5-VL, Med-R1, MedGemma, MedAgent-Pro, MedAgents, MDAgent and LLaVA-Med. These results highlight the importance of region-level semantic alignment and multi-agent collaboration in diagnosing nodules. LungNoduleAgent stands out as a promising foundational tool for supporting clinical analyses of lung nodules.

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JBHI Journal 2025 Journal Article

Cross-Interaction of Chinese Characters Structures and Boundary Features for Improving Clinical Named Entity Recognition

Ye Wang
Qi Wei
Hong Yu
Guoyin Wang
Chunmeng Shi
Dajiang Lei

In the natural language processing task of clinical named entity recognition (CNER), accurately identifying the boundaries and categories of medical entities is crucial. However, traditional methods struggle to recognize a large number of clinical terms and symbols that have never been encountered before, ultimately limiting the performance of CNER. Besides, there exist some easy-to-confuse Chinese clinical entities that are semantically similar but belong to quite different categories, such as “ 肺结节 ” (pulmonary nodules, a symptom entity) and “ 肺结核 ” (pulmonary tuberculosis, a disease entity), which can lead to entity misidentification. To address these problems, we propose a novel NER model called Cross-Interaction of Chinese characters structures and Boundary Features (CCS). The proposed model leverages Chinese character structural features and boundary information to comprehensively and accurately identify confusing entities. We further design a Cross-Attention mechanism to capture dependency relationships between different entities and radicals of characters, enhancing the model's semantic understanding of specialized terms and symbols, as well as improving its ability to recognize boundaries. Our experimental results show that our proposed model outperforms other state-of-the-art models on various public medical datasets, achieving significant improvements on the CCKS2020, CMeEE, CMI, and IMCS datasets, respectively.

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JBHI Journal 2025 Journal Article

Multi-Scale Dynamic Sparse Token Multi-Instance Learning for Pathology Image Classification

Dajiang Lei
Yuqi Zhang
Haodong Wang
Xiaomin Xiong
Bo Xu
Guoyin Wang

In many challenging breast cancer pathology images, the proportion of truly informative tumor regions is extremely limited. The disparity between the essential information required for clinical diagnosis (Tumor area less than 10 $\%$ ) and the vast amount of data within Whole Slide Images (WSIs) makes it exceedingly difficult for pathologists to identify subtle lesions. To address the labor-intensive task imposed by this information gap, this paper proposes a dynamic sparse token based multi-instance learning framework. This framework incorporates a dynamic sparse layer into the transformer architecture, gradually adapting to selectively filter key instances beneficial for the task. Furthermore, to tackle complex scenarios in pathology image tasks, we introduce a weakly supervised cross-scale contrastive learning framework. This framework leverages pathology image features at different scales to perform contrastive learning at the bag-level representation to overcome existing challenges in multi-scale feature fusion in pathology image tasks. To validate the effectiveness and transferability of the model, we conducted various single-scale and multi-scale experiments across four cancer datasets and conducted interpretable analyses. Compared to other state-of-the-art methods, our classification model demonstrates superior performance across six evaluation metrics.

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