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Da-Woon Heo

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AAAI Conference 2026 Conference Paper

HyFI: Hyperbolic Feature Interpolation for Brain-Vision Alignment

  • Sangmin Jo
  • Wootaek Jeong
  • Da-Woon Heo
  • Yoohwan Hwang
  • Heung-Il Suk

Recent progress in artificial intelligence has encouraged numerous attempts to understand and decode human visual system from brain signals. These prior works typically align neural activity independently with semantic and perceptual features extracted from images using pre-trained vision models. However, they fail to account for two key challenges: (1) the modality gap arising from the natural difference in the information level of representation between brain signals and images, and (2) the fact that semantic and perceptual features are highly entangled within neural activity. To address these issues, we utilize hyperbolic space, which is well-suited for considering differences in the amount of information and has the geometric property that geodesics between two points naturally bend toward the origin, where the representational capacity is lower. Leveraging these properties, we propose a novel framework, Hyperbolic Feature Interpolation (HyFI), which interpolates between semantic and perceptual visual features along hyperbolic geodesics. This enables both the fusion and compression of perceptual and semantic information, effectively reflecting the limited expressiveness of brain signals and the entangled nature of these features. As a result, it facilitates better alignment between brain and visual features. We demonstrate that HyFI achieves state-of-the-art performance in zero-shot brain-to-image retrieval, outperforming prior methods with Top-1 accuracy improvements of up to +17.3% on THINGS-EEG and +9.1% on THINGS-MEG.

YNIMG Journal 2025 Journal Article

A quantitatively interpretable model for Alzheimer’s disease prediction using deep counterfactuals

  • Kwanseok Oh
  • Da-Woon Heo
  • Ahmad Wisnu Mulyadi
  • Wonsik Jung
  • Eunsong Kang
  • Kun Ho Lee
  • Heung-Il Suk

Deep learning (DL) for predicting Alzheimer's disease (AD) has provided timely intervention in disease progression yet still demands attentive interpretability to explain how their DL models make definitive decisions. Counterfactual reasoning has recently gained increasing attention in medical research because of its ability to provide a refined visual explanatory map. However, such visual explanatory maps based on visual inspection alone are insufficient unless we intuitively demonstrate their medical or neuroscientific validity via quantitative features. In this study, we synthesize the counterfactual-labeled structural MRIs using our proposed framework and transform it into a gray matter density map to measure its volumetric changes over the parcellated region of interest (ROI). We also devised a lightweight linear classifier to boost the effectiveness of constructed ROIs, promoted quantitative interpretation, and achieved comparable predictive performance to DL methods. Throughout this, our framework produces an "AD-relatedness index" for each ROI. It offers an intuitive understanding of brain status for an individual patient and across patient groups concerning AD progression.

v2026.09.13