Author name cluster

Chris Bowen

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5 papers

2 author rows

YNIMG Journal 2022 Journal Article

Top-down threat bias in pain perception is predicted by intrinsic structural and functional connections of the brain

Guillermo Aristi
Christopher O'Grady
Chris Bowen
Steven Beyea
Sara W. Lazar
Javeria Ali Hashmi

Top-down processes such as expectations play a key role in pain perception. In specific contexts, inferred threat of impending pain can affect perceived pain more than the noxious intensity. This biasing effect of top-down threats can affect some individuals more strongly than others due to differences in fear of pain. The specific characteristics of intrinsic brain characteristics that mediate the effects of top-down threat bias are mainly unknown. In this study, we examined whether threat bias is associated with structural and functional brain connectivity. The variability in the top-down bias was mapped to the microstructure of white matter in diffusion weighted images (DWI) using MRTrix3. Mean functional connectivity of five canonical resting state networks was tested for association with bias scores and with the identified DWI metrics. We found that the fiber density of the splenium of the corpus callosum was significantly low in individuals with high top-down threat bias (FWE corrected with 5000 permutations, p < 0.05). The mean functional connectivity within the language/memory and between language/memory and default mode networks predicted the bias scores. Functional connectivity within language memory networks predicted the splenium fiber density, higher pain catastrophizing and lower mindful awareness. Probabilistic tractography showed that the identified region in the splenium connected several sensory regions and high-order parietal regions between the two hemispheres, indicating the splenium's role in sensory integration. These findings demonstrate that individuals who show more change in pain with changes in the threat of receiving a stronger noxious stimulus have lower structural connectivity in the pathway necessary for integrating top-down cue information with bottom-up sensory information. Conversely, systems involved in memory recall, semantic and self-referential processing are more strongly connected in people with top-down threat bias.

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YNICL Journal 2020 Journal Article

Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression

Lyna Kamintsky
Kathleen A. Cairns
Ronel Veksler
Chris Bowen
Steven D. Beyea
Alon Friedman
Cynthia Calkin

Bipolar disorder affects approximately 2% of the population and is typically characterized by recurrent episodes of mania and depression. While some patients achieve remission using mood-stabilizing treatments, a significant proportion of patients show progressive changes in symptomatology over time. Bipolar progression is diverse in nature and may include a treatment-resistant increase in the frequency and severity of episodes, worse psychiatric and functional outcomes, and a greater risk of suicide. The mechanisms underlying bipolar disorder progression remain poorly understood and there are currently no biomarkers for identifying patients at risk. The objective of this study was to explore the potential of blood-brain barrier (BBB) imaging as such a biomarker, by acquiring the first imaging data of BBB leakage in bipolar patients, and evaluating the potential association between BBB dysfunction and bipolar symptoms. To this end, a cohort of 36 bipolar patients was recruited through the Mood Disorders Clinic (Nova Scotia Health Authority, Canada). All patients, along with 14 control subjects (matched for sex, age and metabolic status), underwent contrast-enhanced dynamic MRI scanning for quantitative assessment of BBB leakage as well as clinical and psychiatric evaluations. Outlier analysis has identified a group of 10 subjects with significantly higher percentages of brain volume with BBB leakage (labeled the "extensive BBB leakage" group). This group consisted exclusively of bipolar patients, while the "normal BBB leakage" group included the entire control cohort and the remaining 26 bipolar subjects. Among the bipolar cohort, patients with extensive BBB leakage were found to have more severe depression and anxiety, and a more chronic course of illness. Furthermore, all bipolar patients within this group were also found to have co-morbid insulin resistance, suggesting that insulin resistance may increase the risk of BBB dysfunction in bipolar patients. Our findings demonstrate a clear link between BBB leakage and greater psychiatric morbidity in bipolar patients and highlight the potential of BBB imaging as a mechanism-based biomarker for bipolar disorder progression.

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ICRA Conference 2018 Conference Paper

Kinematic Design Optimization of a Parallel Surgical Robot to Maximize Anatomical Visibility via Motion Planning

Alan Kuntz
Chris Bowen
Cenk Baykal
Arthur W. Mahoney
Patrick L. Anderson
Fabien Maldonado
Robert J. Webster III
Ron Alterovitz

We introduce a method to optimize on a patient-specific basis the kinematic design of the Continuum Reconfigurable Incisionless Surgical Parallel (CRISP) robot, a needle-diameter medical robot based on a parallel structure that is capable of performing minimally invasive procedures. Our objective is to maximize the ability of the robot's tip camera to view tissue surfaces in constrained spaces. The kinematic design of the CRISP robot, which greatly influences its ability to perform a task, includes parameters that are fixed before the procedure begins, such as entry points into the body and parallel structure connection points. We combine a global stochastic optimization algorithm, Adaptive Simulated Annealing (ASA), with a motion planner designed specifically for the CRISP robot. ASA facilitates exploration of the robot's design space while the motion planner enables evaluation of candidate designs based on their ability to successfully view target regions on a tissue surface. By leveraging motion planning, we ensure that the evaluation of a design only considers motions which do not collide with the patient's anatomy. We analytically show that the method asymptotically converges to a globally optimal solution and demonstrate our algorithm's ability to optimize kinematic designs of the CRISP robot on a patient-specific basis.

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YNIMG Journal 2017 Journal Article

Magnetic resonance fingerprinting based on realistic vasculature in mice

Philippe Pouliot
Louis Gagnon
Tina Lam
Pramod K. Avti
Chris Bowen
Michèle Desjardins
Ashok K. Kakkar
Eric Thorin

Magnetic resonance fingerprinting (MRF) was recently proposed as a novel strategy for MR data acquisition and analysis. A variant of MRF called vascular MRF (vMRF) followed, that extracted maps of three parameters of physiological importance: cerebral oxygen saturation (SatO2), mean vessel radius and cerebral blood volume (CBV). However, this estimation was based on idealized 2-dimensional simulations of vascular networks using random cylinders and the empirical Bloch equations convolved with a diffusion kernel. Here we focus on studying the vascular MR fingerprint using real mouse angiograms and physiological values as the substrate for the MR simulations. The MR signal is calculated ab initio with a Monte Carlo approximation, by tracking the accumulated phase from a large number of protons diffusing within the angiogram. We first study the identifiability of parameters in simulations, showing that parameters are fully estimable at realistically high signal-to-noise ratios (SNR) when the same angiogram is used for dictionary generation and parameter estimation, but that large biases in the estimates persist when the angiograms are different. Despite these biases, simulations show that differences in parameters remain estimable. We then applied this methodology to data acquired using the GESFIDE sequence with SPIONs injected into 9 young wild type and 9 old atherosclerotic mice. Both the pre injection signal and the ratio of post-to-pre injection signals were modeled, using 5-dimensional dictionaries. The vMRF methodology extracted significant differences in SatO2, mean vessel radius and CBV between the two groups, consistent across brain regions and dictionaries. Further validation work is essential before vMRF can gain wider application.

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IROS Conference 2014 Conference Paper

Closed-loop global motion planning for reactive execution of learned tasks

Chris Bowen
Ron Alterovitz

We present a motion planning approach for performing a learned task while avoiding obstacles and reacting to the movement of task-relevant objects. We employ a closed-loop sampling-based motion planner that acquires new sensor information, generates new collision-free plans that are based on a learned task model, and replans at an average rate of more than 10 times per second for a 7-DOF manipulator. The task model is learned from expert demonstrations prior to task execution and is represented as a hidden Markov model. During task execution, our motion planner quickly searches in the Cartesian product of the task model and a probabilistic roadmap for a plan with features most similar to the demonstrations given the locations of the task-relevant objects. We improve the replan rate by using a fast bidirectional search and by biasing the sampling distribution using information from the learned task model to construct high-quality roadmaps. We illustrate the efficacy of our approach by performing a simulated navigation task with a 2D point robot and a physical powder transfer task with the Baxter robot.

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