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Chanwoo Kim

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4 papers

2 author rows

NeurIPS Conference 2025 Conference Paper

CellCLIP - Learning Perturbation Effects in Cell Painting via Text-Guided Contrastive Learning

MingYu Lu
Ethan Weinberger
Chanwoo Kim
Su-In Lee

High-content screening (HCS) assays based on high-throughput microscopy techniques such as Cell Painting have enabled the interrogation of cells' morphological responses to perturbations at an unprecedented scale. The collection of such data promises to facilitate a better understanding of the relationships between different perturbations and their effects on cellular state. Towards achieving this goal, recent advances in cross-modal contrastive learning could, in theory, be leveraged to learn a unified latent space that aligns perturbations with their corresponding morphological effects. However, the application of such methods to HCS data is not straightforward due to substantial differences in the semantics of Cell Painting images compared to natural images, and the difficulty of representing different classes of perturbations (e. g. small molecule vs CRISPR gene knockout) in a single latent space. In response to these challenges, here we introduce CellCLIP, a cross-modal contrastive learning framework for HCS data. CellCLIP leverages pre-trained image encoders coupled with a novel channel encoding scheme to better capture relationships between different microscopy channels in image embeddings, along with natural language encoders for representing perturbations. Our framework outperforms current open-source models, demonstrating the best performance in both cross-modal retrieval and biologically meaningful downstream tasks while also achieving significant reductions in computation time. Code for our reproducing our experiments is available at https: //github. com/suinleelab/CellCLIP.

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ICRA Conference 2025 Conference Paper

Learning-Based Dynamic Robot-to-Human Handover

Hyeonseong Kim
Chanwoo Kim
Matthew K. X. J. Pan
Kyungjae Lee 0001
Sungjoon Choi

This paper presents a novel learning-based approach to dynamic robot-to-human handover, addressing the challenges of delivering objects to a moving receiver. We hypothesize that dynamic handover, where the robot adjusts to the receiver's movements, results in more efficient and comfortable interaction compared to static handover, where the receiver is assumed to be stationary. To validate this, we developed a nonparametric method for generating continuous handover motion, conditioned on the receiver's movements, and trained the model using a dataset of 1, 000 human-to-human handover demonstrations. We integrated preference learning for improved handover effectiveness and applied impedance control to ensure user safety and adaptiveness. The approach was evaluated in both simulation and real-world settings, with user studies demonstrating that dynamic handover significantly reduces handover time and improves user comfort compared to static methods. Videos and demonstrations of our approach are available at https://zerotohero7886.github.io/dyn-r2h-handover/.

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TMLR Journal 2024 Journal Article

Physics Informed Distillation for Diffusion Models

Joshua Tian Jin Tee
Kang Zhang
Hee Suk Yoon
Dhananjaya Nagaraja Gowda
Chanwoo Kim
Chang D. Yoo

Diffusion models have recently emerged as a potent tool in generative modeling. However, their inherent iterative nature often results in sluggish image generation due to the requirement for multiple model evaluations. Recent progress has unveiled the intrinsic link between diffusion models and Probability Flow Ordinary Differential Equations (ODEs), thus enabling us to conceptualize diffusion models as ODE systems. Simultaneously, Physics Informed Neural Networks (PINNs) have substantiated their effectiveness in solving intricate differential equations through implicit modeling of their solutions. Building upon these foundational insights, we introduce Physics Informed Distillation (PID), which employs a student model to represent the solution of the ODE system corresponding to the teacher diffusion model, akin to the principles employed in PINNs. Through experiments on CIFAR 10 and ImageNet 64x64, we observe that PID achieves performance comparable to recent distillation methods. Notably, it demonstrates predictable trends concerning method-specific hyperparameters and eliminates the need for synthetic dataset generation during the distillation process. Both of which contribute to its easy-to-use nature as a distillation approach for Diffusion Models.

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NeurIPS Conference 2024 Conference Paper

Stochastic Amortization: A Unified Approach to Accelerate Feature and Data Attribution

Ian Covert
Chanwoo Kim
Su-In Lee
James Zou
Tatsunori Hashimoto

Many tasks in explainable machine learning, such as data valuation and feature attribution, perform expensive computation for each data point and are intractable for large datasets. These methods require efficient approximations, and although amortizing the process by learning a network to directly predict the desired output is a promising solution, training such models with exact labels is often infeasible. We therefore explore training amortized models with noisy labels, and we find that this is inexpensive and surprisingly effective. Through theoretical analysis of the label noise and experiments with various models and datasets, we show that this approach tolerates high noise levels and significantly accelerates several feature attribution and data valuation methods, often yielding an order of magnitude speedup over existing approaches.

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