Author name cluster

Bruno Jedynak

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5 papers

2 author rows

NeurIPS Conference 2025 Conference Paper

Optical Coherence Tomography Harmonization with Anatomy-Guided Latent Metric Schrödinger Bridges

Shuwen Wei
Samuel Remedios
Blake Dewey
Zhangxing Bian
Shimeng Wang
Junyu Chen
Bruno Jedynak
shiv saidha

Medical image harmonization aims to reduce the differences in appearance caused by scanner hardware variations to allow for consistent and reliable comparisons across devices. Harmonization based on paired images from different devices has limited applicability in real-world clinical settings. On the other hand, unpaired harmonization typically does not guarantee anatomy consistency, which is problematic because anatomical information preservation is paramount. The Schrödinger bridge framework has achieved state-of-the-art style transfer performance with natural images by matching distributions of unpaired images, but this approach can also introduce anatomy changes when applied to medical images. We show that such changes occur because the Schrödinger bridge uses the square of the Euclidean distance between images as the transport cost in an entropy-regularized optimal transport problem. Such a transport cost is not appropriate for measuring anatomical distances, as medical images with the same anatomy need not have a small Euclidean distance between them. In this paper, we propose a latent metric Schrödinger bridge (LMSB) framework to improve the anatomical consistency for the harmonization of medical images. We develop an invertible network that maps medical images into a latent Euclidean metric space where the distances among images with the same anatomy are minimized using the pullback latent metric. Within this latent space, we train a Schrödinger bridge to match distributions. We show that the proposed LMSB is superior to the direct application of a Schrödinger bridge to harmonize optical coherence tomography (OCT) images.

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NeurIPS Conference 2021 Conference Paper

Learning Riemannian metric for disease progression modeling

Samuel Gruffaz
Pierre-Emmanuel Poulet
Etienne Maheux
Bruno Jedynak
Stanley Durrleman

Linear mixed-effect models provide a natural baseline for estimating disease progression using longitudinal data. They provide interpretable models at the cost of modeling assumptions on the progression profiles and their variability across subjects. A significant improvement is to embed the data in a Riemannian manifold and learn patient-specific trajectories distributed around a central geodesic. A few interpretable parameters characterize subject trajectories at the cost of a prior choice of the metric, which determines the shape of the trajectories. We extend this approach by learning the metric from the data allowing more flexibility while keeping the interpretability. Specifically, we learn the metric as the push-forward of the Euclidean metric by a diffeomorphism. This diffeomorphism is estimated iteratively as the composition of radial basis functions belonging to a reproducible kernel Hilbert space. The metric update allows us to improve the forecasting of imaging and clinical biomarkers in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Our results compare favorably to the 56 methods benchmarked in the TADPOLE challenge.

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ICML Conference 2015 Conference Paper

Bayesian Multiple Target Localization

Purnima Rajan
Weidong Han 0004
Raphael Sznitman
Peter I. Frazier
Bruno Jedynak

We consider the problem of quickly localizing multiple targets by asking questions of the form “How many targets are within this set" while obtaining noisy answers. This setting is a generalization to multiple targets of the game of 20 questions in which only a single target is queried. We assume that the targets are points on the real line, or in a two dimensional plane for the experiments, drawn independently from a known distribution. We evaluate the performance of a policy using the expected entropy of the posterior distribution after a fixed number of questions with noisy answers. We derive a lower bound for the value of this problem and study a specific policy, named the dyadic policy. We show that this policy achieves a value which is no more than twice this lower bound when answers are noise-free, and show a more general constant factor approximation guarantee for the noisy setting. We present an empirical evaluation of this policy on simulated data for the problem of detecting multiple instances of the same object in an image. Finally, we present experiments on localizing multiple faces simultaneously on real images.

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ICML Conference 2013 Conference Paper

An Optimal Policy for Target Localization with Application to Electron Microscopy

Raphael Sznitman
Aurélien Lucchi
Peter I. Frazier
Bruno Jedynak
Pascal Fua

This paper considers the task of finding a target location by making a limited number of sequential observations. Each observation results from evaluating an imperfect classifier of a chosen cost and accuracy on an interval of chosen length and position. Within a Bayesian framework, we study the problem of minimizing an objective that combines the entropy of the posterior distribution with the cost of the questions asked. In this problem, we show that the one-step lookahead policy is Bayes-optimal for any arbitrary time horizon. Moreover, this one-step lookahead policy is easy to compute and implement. We then use this policy in the context of localizing mitochondria in electron microscope images, and experimentally show that significant speed ups in acquisition can be gained, while maintaining near equal image quality at target locations, when compared to current policies.

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YNIMG Journal 2013 Journal Article

Approaching expert results using a hierarchical cerebellum parcellation protocol for multiple inexpert human raters

John A. Bogovic
Bruno Jedynak
Rachel Rigg
Annie Du
Bennett A. Landman
Jerry L. Prince
Sarah H. Ying

Volumetric measurements obtained from image parcellation have been instrumental in uncovering structure–function relationships. However, anatomical study of the cerebellum is a challenging task. Because of its complex structure, expert human raters have been necessary for reliable and accurate segmentation and parcellation. Such delineations are time-consuming and prohibitively expensive for large studies. Therefore, we present a three-part cerebellar parcellation system that utilizes multiple inexpert human raters that can efficiently and expediently produce results nearly on par with those of experts. This system includes a hierarchical delineation protocol, a rapid verification and evaluation process, and statistical fusion of the inexpert rater parcellations. The quality of the raters’ and fused parcellations was established by examining their Dice similarity coefficient, region of interest (ROI) volumes, and the intraclass correlation coefficient of region volume. The intra-rater ICC was found to be 0. 93 at the finest level of parcellation.

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