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Bruce Buchanan

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2 papers

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AAAI Conference 1994 Short Paper

The Crystallographer’s Assistant

Vanathi Gopalakrishnan
Bruce Buchanan

The only routinely used technique available today for obtaining the 3-D structure of a protein or DNA molecule is by X-ray diffracting a crystal of the macromolecule. The rate limiting step in structure determination is the process of growing a crystal of the macromolecule. This process is not very well understood, and can take a few weeks to several years. Crystallographers, therefore, are in great need of tools to aid them in the process of designing and performing experiments. There is a great deal of experiential data in this domain, in the form of scientific notebooks with graphical and textual representations of previous experiments.

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AIJ Journal 1977 Journal Article

Production rules as a representation for a knowledge-based consultation program☆

Randall Davis
Bruce Buchanan
Edward Shortliffe

The MYCIN system has begun to exhibit a high level of performance as a consultant on the difficult task of selecting antibiotic therapy for bacteremia. This report discusses issues of representation and design for the system. We describe the basic task and document the constraints involved in the use of a program as a consultant. The control structure and knowledge representation of the system are examined in this light, and special attention is given to the impact of production rules as a representation. The extent of the domain independence of the approach is also examined.

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