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Boyu Han

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4 papers

2 author rows

NeurIPS Conference 2025 Conference Paper

LightFair: Towards an Efficient Alternative for Fair T2I Diffusion via Debiasing Pre-trained Text Encoders

Boyu Han
Qianqian Xu
Shilong Bao
Zhiyong Yang
Kangli Zi
Qingming Huang

This paper explores a novel lightweight approach LightFair to achieve fair text-to-image diffusion models (T2I DMs) by addressing the adverse effects of the text encoder. Most existing methods either couple different parts of the diffusion model for full-parameter training or rely on auxiliary networks for correction. They incur heavy training or sampling burden and unsatisfactory performance. Since T2I DMs consist of multiple components, with the text encoder being the most fine-tunable and front-end module, this paper focuses on mitigating bias by fine-tuning text embeddings. To validate feasibility, we observe that the text encoder’s neutral embedding output shows substantial skewness across image embeddings of various attributes in the CLIP space. More importantly, the noise prediction network further amplifies this imbalance. To finetune the text embedding, we propose a collaborative distance-constrained debiasing strategy that balances embedding distances to improve fairness without auxiliary references. However, mitigating bias can compromise the original generation quality. To address this, we introduce a two-stage text-guided sampling strategy to limit when the debiased text encoder intervenes. Extensive experiments demonstrate that LightFair is effective and efficient. Notably, on Stable Diffusion v1. 5, our method achieves SOTA debiasing at just $1/4$ of the training burden, with virtually no increase in sampling burden. The code is available at https: //github. com/boyuh/LightFair.

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NeurIPS Conference 2024 Conference Paper

AUCSeg: AUC-oriented Pixel-level Long-tail Semantic Segmentation

Boyu Han
Qianqian Xu
Zhiyong Yang
Shilong Bao
Peisong Wen
Yangbangyan Jiang
Qingming Huang

The Area Under the ROC Curve (AUC) is a well-known metric for evaluating instance-level long-tail learning problems. In the past two decades, many AUC optimization methods have been proposed to improve model performance under long-tail distributions. In this paper, we explore AUC optimization methods in the context of pixel-level long-tail semantic segmentation, a much more complicated scenario. This task introduces two major challenges for AUC optimization techniques. On one hand, AUC optimization in a pixel-level task involves complex coupling across loss terms, with structured inner-image and pairwise inter-image dependencies, complicating theoretical analysis. On the other hand, we find that mini-batch estimation of AUC loss in this case requires a larger batch size, resulting in an unaffordable space complexity. To address these issues, we develop a pixel-level AUC loss function and conduct a dependency-graph-based theoretical analysis of the algorithm's generalization ability. Additionally, we design a Tail-Classes Memory Bank (T-Memory Bank) to manage the significant memory demand. Finally, comprehensive experiments across various benchmarks confirm the effectiveness of our proposed AUCSeg method. The code is available at https: //github. com/boyuh/AUCSeg.

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NeurIPS Conference 2024 Conference Paper

Cell ontology guided transcriptome foundation model

Xinyu Yuan
Zhihao Zhan
Zuobai Zhang
Manqi Zhou
Jianan Zhao
Boyu Han
Yue Li
Jian Tang

Transcriptome foundation models (TFMs) hold great promises of deciphering the transcriptomic language that dictate diverse cell functions by self-supervised learning on large-scale single-cell gene expression data, and ultimately unraveling the complex mechanisms of human diseases. However, current TFMs treat cells as independent samples and ignore the taxonomic relationships between cell types, which are available in cell ontology graphs. We argue that effectively leveraging this ontology information during the TFM pre-training can improve learning biologically meaningful gene co-expression patterns while preserving TFM as a general purpose foundation model for downstream zero-shot and fine-tuning tasks. To this end, we present s ingle c ell, Cell - o ntology guided TFM (scCello). We introduce cell-type coherence loss and ontology alignment loss, which are minimized along with the masked gene expression prediction loss during the pre-training. The novel loss component guide scCello to learn the cell-type-specific representation and the structural relation between cell types from the cell ontology graph, respectively. We pre-trained scCello on 22 million cells from CellxGene database leveraging their cell-type labels mapped to the cell ontology graph from Open Biological and Biomedical Ontology Foundry. Our TFM demonstrates competitive generalization and transferability performance over the existing TFMs on biologically important tasks including identifying novel cell types of unseen cells, prediction of cell-type-specific marker genes, and cancer drug responses. Source code and modelweights are available at https: //github. com/DeepGraphLearning/scCello.

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ICML Conference 2024 Conference Paper

Harnessing Hierarchical Label Distribution Variations in Test Agnostic Long-tail Recognition

Zhiyong Yang 0001
Qianqian Xu 0001
Zitai Wang
Sicong Li
Boyu Han
Shilong Bao
Xiaochun Cao
Qingming Huang

This paper explores test-agnostic long-tail recognition, a challenging long-tail task where the test label distributions are unknown and arbitrarily imbalanced. We argue that the variation in these distributions can be broken down hierarchically into global and local levels. The global ones reflect a broad range of diversity, while the local ones typically arise from milder changes, often focused On a particular neighbor. Traditional methods predominantly use a Mixture-of-Expert (MoE) approach, targeting a few fixed test label distributions that exhibit substantial global variations. However, the local variations are left unconsidered. To address this issue, we propose a new MoE strategy, $\mathsf{DirMixE}$, which assigns experts to different Dirichlet meta-distributions of the label distribution, each targeting a specific aspect of local variations. Additionally, the diversity among these Dirichlet meta-distributions inherently captures global variations. This dual-level approach also leads to a more stable objective function, allowing us to sample different test distributions better to quantify the mean and variance of performance outcomes. Theoretically, we show that our proposed objective benefits from enhanced generalization by virtue of the variance-based regularization. Comprehensive experiments across multiple benchmarks confirm the effectiveness of $\mathsf{DirMixE}$.

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