EAAI Journal 2025 Journal Article
Reading comprehension powered semantic fusion network for identification of N-ary drug combinations
- Hua Zhang
- Peiqian Zhan
- Cheng Yang
- Yongjian Yan
- Zijing Cai
- Guogen Shan
- Bo Jiang
- Bi Chen
The concurrent use of multiple medications to treat one or more diseases is prevalent. Identifying N-ary drug combinations from biomedical texts aids in uncovering significant pharmacological effects triggered by drug-drug interactions. Previous methods for this emerging task have primarily concentrated on representing drug entities using pre-trained language models, overlooking the comprehensive extraction of contextual and task-specific semantic information. To address these limitations, we develop a semantic fusion method grounded in machine reading comprehension (MRC) framework. Our model, termed Reading Comprehension powered semantic Fusion network for Identification of N-ary Drug combinations (RCFIND), first constructs relevant contexts and queries for each individual drug combination. Then, diverse information sources, including task-specific semantics, drug entity representations and contextual details, are fused by using a simplified Capsule network as well as incorporating contrastive learning. We assess RCFIND, achieving F1 scores ranging from 72. 0% to 83. 3% across four types of evaluations. Experimental results demonstrate significant performance enhancements over existing baselines, with at least a 5% F1 score improvement. Ablation studies and further analysis confirm the efficacy of the MRC framework and contrastive learning in accurately identifying N-ary drug combinations.