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Benyan Luo

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4 papers
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4

AAAI Conference 2025 Conference Paper

Personalized Sleep Staging Leveraging Source-free Unsupervised Domain Adaptation

  • Yangxuan Zhou
  • Sha Zhao
  • Jiquan Wang
  • Haiteng Jiang
  • Shijian Li
  • Benyan Luo
  • Tao Li
  • Gang Pan

Sleep staging is important for monitoring sleep quality and diagnosing sleep-related disorders. Recently, numerous deep learning-based models have been proposed for automatic sleep staging using polysomnography recordings. Most of them are trained and tested on the same labeled datasets which results in poor generalization to unseen target domains. However, they regard the subjects in the target domains as a whole and overlook the individual discrepancies, which limits the model's generalization ability to new patients (i.e., unseen subjects) and plug-and-play applicability in clinics. To address this, we propose a novel Source-Free Unsupervised Individual Domain Adaptation (SF-UIDA) framework for sleep staging, leveraging sequential cross-view contrasting and pseudo-label based fine-tuning. It is actually a two-step subject-specific adaptation scheme, which enables the source model to effectively adapt to newly appeared unlabeled individual without access to the source data. It meets the practical needs in real-world scenarios, where the personalized customization can be plug-and-play applied to new ones. Our framework is applied to three classic sleep staging models and evaluated on three public sleep datasets, achieving the state-of-the-art performance.

YNICL Journal 2022 Journal Article

Rhythmic musical-electrical trigeminal nerve stimulation improves impaired consciousness

  • Min Wu
  • Benyan Luo
  • Yamei Yu
  • Xiaoxia Li
  • Jian Gao
  • Jingqi Li
  • Bettina Sorger
  • Lars Riecke

Accumulating evidence shows that consciousness is linked to neural oscillations in the thalamocortical system, suggesting that deficits in these oscillations may underlie disorders of consciousness (DOC). However, patient-friendly non-invasive treatments targeting this functional anomaly are still missing and the therapeutic value of oscillation restoration has remained unclear. We propose a novel approach that aims to restore DOC patients' thalamocortical oscillations by combining rhythmic trigeminal-nerve stimulation with comodulated musical stimulation ("musical-electrical TNS"). In a double-blind, placebo-controlled, parallel-group study, we recruited 63 patients with DOC and randomly assigned them to groups receiving gamma, beta, or sham musical-electrical TNS. The stimulation was applied for 40 min on five consecutive days. We measured patients' consciousness before and after the stimulation using behavioral indicators and neural responses to rhythmic auditory speech. We further assessed their outcomes one year later. We found that musical-electrical TNS reliably lead to improvements in consciousness and oscillatory brain activity at the stimulation frequency: 43.5 % of patients in the gamma group and 25 % of patients in the beta group showed an improvement of their diagnosis after being treated with the stimulation. This group of benefitting patients still showed more positive outcomes one year later. Moreover, patients with stronger behavioral benefits showed stronger improvements in oscillatory brain activity. These findings suggest that brain oscillations contribute to consciousness and that musical-electrical TNS may serve as a promising approach to improve consciousness and predict long-term outcomes in patients with DOC.

YNICL Journal 2021 Journal Article

Fixel-based evidence of microstructural damage in crossing pathways improves language mapping in Post-stroke aphasia

  • Jie Zhang
  • Weihao Zheng
  • Desheng Shang
  • Yating Chen
  • Shuchang Zhong
  • Jing Ye
  • Lingling Li
  • Yamei Yu

BACKGROUND: The complex crossing-fiber characteristics in the dual-stream system have been ignored by traditional diffusion tensor models regarding disconnections in post-stroke aphasia. It is valuable to identify microstructural damage of crossing-fiber pathways and reveal accurate fiber-specific language mapping in patients with aphasia. METHODS: This cross-sectional study collected magnetic resonance imaging data from 29 participants with post-stroke aphasia in the subacute stage and from 33 age- and sex-matched healthy controls. Fixel-based analysis was performed to examine microstructural fiber density (FD) and bundle cross-section alterations of specific fiber populations in crossing-fiber regions. Group comparisons were performed, and relationships with language scores were assessed. RESULTS: The aphasic group exhibited significant fixel-wise FD reductions in the dual-stream tracts, including the left inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus, and superior longitudinal fasciculus (SLF) III (family-wise-error-corrected p < 0.05). Voxel- and fixel-wise comparisons revealed mismatched distributions in regions with crossing-fiber nexuses. Fixel-wise correlation analyses revealed significant associations between comprehension impairment and reduced FD in the temporal and frontal segments of the left IFOF, and also mapped naming ability to the IFOF. Average features along the whole course of dominant tracts assessed with tract-wise analyses attributed word-level comprehension to the IFOF (r = 0.723, p < 0.001) and revealed a trend-level correlation between sentence-level comprehension and FD of the SLF III (r = 0.451, p = 0.021). The mean FD of the uncinate fasciculus (UF) and IFOF correlated with total and picture naming scores, and the IFOF also correlated with responsive naming subdomains (Bonferroni corrected p < 0.05). CONCLUSIONS: FD reductions of dual streams suggest that intra-axonal volume reduction constitutes the microstructural damage of white matter integrity in post-stroke aphasia. Fixel-based analysis provides a complementary method of language mapping that identifies fiber-specific tracts in the left hemisphere language network with greater specificity than voxel-based analysis. It precisely locates the precise segments of the IFOF for comprehension, yields fiber-specific evidence for the debated UF-naming association, and reveals dissociative subdomain associations with distinct tracts.

YNICL Journal 2019 Journal Article

Structural connectome alterations in patients with disorders of consciousness revealed by 7-tesla magnetic resonance imaging

  • Xufei Tan
  • Zhen Zhou
  • Jian Gao
  • Fanxia Meng
  • Yamei Yu
  • Jie Zhang
  • Fangping He
  • Ruili Wei

Although the functional connectivity of patients with disorders of consciousness (DOC) has been widely examined, less is known about brain white matter connectivity. The aim of this study was to explore structural network alterations for the diagnosis and prognosis of patients with chronic DOC. Eleven DOC patients and 11 sex- and age-matched controls were included in the study. Participants underwent diffusion magnetic resonance imaging (MRI) and T1-weighted structural MRI at 7 tesla (7 T). Graph-theoretical analysis and network-based statistics were used to analyze the group differences. Two patients were scanned twice for a longitudinal study to examine the relationship between connectome metrics and the patients' prognoses. Compared with healthy controls, DOC patients showed significantly elevated transitivity (p < .001), local efficiency (p = .009), and clustering coefficient (p = .039). When comparing the connectome metrics within the three groups (healthy controls, minimally conscious state (MCS), and vegetative state/unresponsive wakefulness syndrome (VS/UWS)), significant group differences were observed in transitivity (p < .001) and local efficiency (p = .031). Significantly increased transitivity was observed in vegetative state/unresponsive wakefulness syndrome compared with minimally conscious state (p = .0217, Bonferroni corrected). Transitivity showed significant negative correlations with the Coma Recovery Scale-Revised score (r = -0.6902, p = .023), consistent with the longitudinal study results. A subnetwork with significantly decreased structural connections was identified using network-based statistical analysis comparing DOC patients with healthy controls, which was mainly located in the frontal cortex, limbic system, and occipital and parietal lobes. This preliminary study suggests that graph theoretical approaches for assessing white matter connectivity may enable various states of DOC to be distinguished. Of the metrics analyzed, transitivity had a critical role in distinguishing the diagnostic groups. Larger cohorts will be necessary to confirm the predictive value of 7 T MRI in the prognosis of DOC patients.

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