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Baoci Shan

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6 papers

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YNIMG Journal 2026 Journal Article

Gestational age-specific DTI templates of the neonatal brain: Application in preterm developmental study

Xiaochen Jiang
Mengyi Wang
Ying Liu
Tianhao Zhang
Guangjuan Mao
Qi Zhou
Shilun Zhao
Baoci Shan

Due to significant differences in brain volume, morphology, and white matter integrity among neonates of varying gestational ages, using a single full-term template for preterm analysis inevitably introduces analytical errors. To address this, we aimed to develop gestational-age-specific stereotaxic DTI templates using retrospective diffusion MRI scans from 161 neonates acquired between August 2021 and January 2024. The cohort was stratified into four WHO-defined subgroups: extremely preterm (n = 31), very preterm (n = 29), moderate to late preterm (n = 28), and full-term (n = 73). Templates were constructed via iterative registration, with corresponding atlases transformed from JHU space and manually corrected. Quantitative evaluation using the Jacobian determinant and standard deviation revealed that our age-specific templates demonstrated significantly lower deformation magnitude and registration error compared to a standard full-term template. When applied to investigate developmental differences, we observed progressively more extensive fractional anisotropy reductions from moderate-to-late to extremely preterm neonates. Notably, commissural fibers, particularly the corpus callosum body (0.194 ± 0.005 in extremely preterm vs. 0.230 ± 0.003 in full-term, p < 0.001), exhibited significant developmental gradients. Consequently, these constructed gestational-age-specific DTI templates offer a robust tool to improve the accuracy of morbidity risk predictions and facilitate multicenter studies of preterm neonates.

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YNIMG Journal 2025 Journal Article

Brain development during the lifespan of cynomolgus monkeys

Zhiqiang Tan
Binbin Nie
Huanhua Wu
Bang Li
Jingjie Shang
Tianhao Zhang
Zeyu Xiao
Chenchen Dong

F]FDG PET-MRI data from 228 healthy cynomolgus monkeys spanning the age range of 0.5-29.5 years to construct an age-specific multimodal image brain template toolset tailored to cynomolgus monkeys. Their brain volume and glucose metabolism were quantitatively analyzed by utilizing an individualized spatial segmentation algorithm. Our findings encapsulated the growth and development trends, sex differences, and asymmetrical variations in brain volume and glucose metabolism in cynomolgus monkeys, and analyzed the correlation between the brain volume and glucose metabolism. This endeavor enhances our capacity to leverage the cynomolgus monkey model in neuroscience research by providing a valuable resource for researchers. The age-specific brain template toolset and associated data offer a robust foundation for future investigations, facilitating a nuanced understanding of brain development in this primate species and, consequently, informing and advancing neuroscience research employing cynomolgus monkeys.

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YNICL Journal 2020 Journal Article

Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients

Yuqi Cheng
Jian Xu
Chenglong Dong
Zonglin Shen
Cong Zhou
Na Li
Yi Lu
Liuyi Ran

Brain ageing is thought to be related to geriatric depression, but the relationship between ageing and depression among middle aged individuals is unknown. The present study aimed to evaluate whether the age-related reduction of brain cortical thickness (CT) can be found in adult first-episode MDD patients, as well as to identify the possible genetic effect of the ANK3 gene polymorphism age-relates CT reduction. This study recruited 153 first-episode MDD patients with a disease duration < 2 years and 276 healthy controls (HC), and the CT of 68 whole brain regions and two ANK3 SNPs (rs1994336 and rs10994359) were analyzed. The results showed that although the CT of both groups was negative correlated with age, the MDD group had significant greater age-related decrease in CT than the HC group (–9. 35 × 10−3 mm/year for MDD vs. –1. 23 × 10−3 mm/year for HC in the left lateral orbitofrontal lobe). The multivariate analysis of covariance (MANCOVA) results yielded significant interactions of diagnosis × age, genotype × age and diagnosis × genotype interaction for rs10994359. In HC, the C allele showed a protective effect on age-related CT reduction. The reduction in CT with age was several times as greater in non-C carriers as in C carriers (–3. 54 × 10−3 vs. –0. 15 × 10−3 mm/year in left supramarginal gyrus) for HC. However, this protective effect disappeared in patients with MDD. We did not find a clear effect of rs1994336 on the age-related CT reduction. The findings indicate that the widespread accelerated brain ageing occurs early in adult-onset depression and this ageing may be a pathological mechanisms of depression rather than an outcome of the disease. The ANK3 rs10994359 polymorphism may partially affect regional cortical ageing in MDD.

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YNIMG Journal 2019 Journal Article

A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model

Binbin Nie
Lu Wang
Yichao Hu
Shengxiang Liang
Zhiqiang Tan
Pei Chai
Yongjin Tang
Jingjie Shang

Purpose Positron emission tomography (PET) is a non-invasive imaging tool for the evaluation of brain function and neuronal activity in normal and diseased conditions with high sensitivity. The macaque monkey serves as a valuable model system in the field of translational medicine, for its phylogenetic proximity to man. To translation of non-human primate neuro-PET studies, an effective and objective data analysis platform for neuro-PET studies is needed. Materials and methods A set of stereotaxic templates of macaque brain, namely the Institute of High Energy Physics & Jinan University Macaque Template (HJT), was constructed by iteratively registration and averaging, based on 30 healthy rhesus monkeys. A brain atlas image was created in HJT space by combining sub-anatomical regions and defining new 88 bilateral functional regions, in which a unique integer was assigned for each sub-anatomical region. Results The HJT comprised a structural MRI T1 weighted image (T1WI) template image, a functional FDG-PET template image, intracranial tissue segmentations accompanied with a digital macaque brain atlas image. It is compatible with various commercially available software tools, such as SPM and PMOD. Data analysis was performed on a stroke model compared with a group of healthy controls to demonstrate the usage of HJT. Conclusion We have constructed a stereotaxic template set of macaque brain named HJT, which standardizes macaque neuroimaging data analysis, supports novel radiotracer development and facilitates translational neuro-disorders research.

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YNIMG Journal 2019 Journal Article

Detection of neural connections with ex vivo MRI using a ferritin-encoding trans-synaptic virus

Ning Zheng
Peng Su
Yue Liu
Huadong Wang
Binbin Nie
Xiaohui Fang
Yue Xu
Kunzhang Lin

The elucidation of neural networks is essential to understanding the mechanisms of brain functions and brain disorders. Neurotropic virus-based trans-synaptic tracing tools have become an effective method for dissecting the structure and analyzing the function of neural-circuitry. However, these tracing systems rely on fluorescent signals, making it hard to visualize the panorama of the labeled networks in mammalian brain in vivo. One MRI method, Diffusion Tensor Imaging (DTI), is capable of imaging the networks of the whole brain in live animals but without information of anatomical connections through synapses. In this report, a chimeric gene coding for ferritin and enhanced green fluorescent protein (EGFP) was integrated into Vesicular stomatitis virus (VSV), a neurotropic virus that is able to spread anterogradely in synaptically connected networks. After the animal was injected with the recombinant VSV (rVSV), rVSV-Ferritin-EGFP, into the somatosensory cortex (SC) for four days, the labeled neural-network was visualized in the postmortem whole brain with a T2-weighted MRI sequence. The modified virus transmitted from SC to synaptically connected downstream regions. The results demonstrate that rVSV-Ferritin-EGFP could be used as a bimodal imaging vector for detecting synaptically connected neural-network with both ex vivo MRI and fluorescent imaging. The strategy in the current study has the potential to longitudinally monitor the global structure of a given neural-network in living animals.

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YNIMG Journal 2019 Journal Article

Modular architecture of metabolic brain network and its effects on the spread of perturbation impact

Tianhao Zhang
Qi Huang
Chunxiang Jiao
Hua Liu
Binbin Nie
Shengxiang Liang
Panlong Li
Xi Sun

Metabolic brain network, which is based on functional correlation patterns of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) images, has been widely applied in both basic and clinical neuroscience. Exploring the properties of the metabolic brain network can provide valuable insight to the physiologic and pathologic processes of the brain. Based on the network theory, modular architecture has the ability to limit the spread of local perturbation impact and therefore modular networks are more robust against external damage. However, whether the metabolic brain network has modular architecture remains unknown. Methods 77 rats performed 18F-FDG PET brain imaging. The metabolic brain network was then constructed by measuring interregional metabolic correlation in inter-subject manner. Afterwards, modular architecture of the network was detected by a greedy algorithm. Further, we perturbed the metabolic brain network by inducing focal photothrombotic ischemia in the bilateral motor cortex and then measured the glucose metabolic change of each brain region using FDG-PET. Results A significant modular architecture was found in the metabolic brain network. The network could be divided into four modules which corresponding approximately to executive, learning/memory, visual/auditory and sensorimotor processing functional domains. After inducing the focal ischemia on the bilateral motor cortex, most of the significantly changed brain regions (13 of 17) belong to the sensorimotor module. Conclusion Our results revealed an inherent modular architecture in the metabolic brain network and gave an experimental evidence that the modularity of the metabolism brain network could limit the spread of local perturbation impact.

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