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Ashraf Khalil

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

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2

AIIM Journal 2025 Journal Article

AI-based non-invasive imaging technologies for early autism spectrum disorder diagnosis: A short review and future directions

  • Mostafa Abdelrahim
  • Mohamed Khudri
  • Ahmed Elnakib
  • Mohamed Shehata
  • Kate Weafer
  • Ashraf Khalil
  • Gehad A. Saleh
  • Nihal M. Batouty

Autism Spectrum Disorder (ASD) is a neurological condition, with recent statistics from the CDC indicating a rising prevalence of ASD diagnoses among infants and children. This trend emphasizes the critical importance of early detection, as timely diagnosis facilitates early intervention and enhances treatment outcomes. Consequently, there is an increasing urgency for research to develop innovative tools capable of accurately and objectively identifying ASD in its earliest stages. This paper offers a short overview of recent advancements in non-invasive technology for early ASD diagnosis, focusing on an imaging modality, structural MRI technique, which has shown promising results in early ASD diagnosis. This brief review aims to address several key questions: (i) Which imaging radiomics are associated with ASD? (ii) Is the parcellation step of the brain cortex necessary to improve the diagnostic accuracy of ASD? (iii) What databases are available to researchers interested in developing non-invasive technology for ASD? (iv) How can artificial intelligence tools contribute to improving the diagnostic accuracy of ASD? Finally, our review will highlight future trends in ASD diagnostic efforts.

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YNICL Journal 2020 Journal Article

A novel computer-aided diagnosis system for the early detection of hypertension based on cerebrovascular alterations

  • Heba Kandil
  • Ahmed Soliman
  • Fatma Taher
  • Mohammed Ghazal
  • Ashraf Khalil
  • Guruprasad Giridharan
  • Robert Keynton
  • J. Richard Jennings

Hypertension is a leading cause of mortality in the USA. While simple tools such as the sphygmomanometer are widely used to diagnose hypertension, they could not predict the disease before its onset. Clinical studies suggest that alterations in the structure of human brains' cerebrovasculature start to develop years before the onset of hypertension. In this research, we present a novel computer-aided diagnosis (CAD) system for the early detection of hypertension. The proposed CAD system analyzes magnetic resonance angiography (MRA) data of human brains to detect and track the cerebral vascular alterations and this is achieved using the following steps: i) MRA data are preprocessed to eliminate noise effects, correct the bias field effect, reduce the contrast inhomogeneity using the generalized Gauss-Markov random field (GGMRF) model, and normalize the MRA data, ii) the cerebral vascular tree of each MRA volume is segmented using a 3-D convolutional neural network (3D-CNN), iii) cerebral features in terms of diameters and tortuosity of blood vessels are estimated and used to construct feature vectors, iv) feature vectors are then used to train and test various artificial neural networks to classify data into two classes; normal and hypertensive. A balanced data set of 66 subjects were used to test the CAD system. Experimental results reported a classification accuracy of 90.9% which supports the efficacy of the CAD system components to accurately model and discriminate between normal and hypertensive subjects. Clinicians would benefit from the proposed CAD system to detect and track cerebral vascular alterations over time for people with high potential of developing hypertension and to prepare appropriate treatment plans to mitigate adverse events.

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