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Arnaud Boré

Possible papers associated with this exact author name in Arrow. This page groups case-insensitive exact name matches and is not a full identity disambiguation profile.

3 papers

1 author row

YNICL Journal 2022 Journal Article

Medial temporal lobe and obstructive sleep apnea: Effect of sex, age, cognitive status and free-water

Marie-Ève Martineau-Dussault
Claire André
Véronique Daneault
Andrée-Ann Baril
Katia Gagnon
Hélène Blais
Dominique Petit
Jacques Y. Montplaisir

Medial temporal structures, namely the hippocampus, the entorhinal cortex and the parahippocampal gyrus, are particularly vulnerable to Alzheimer's disease and hypoxemia. Here, we tested the associations between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes in 114 participants aged 55-86 years (35 % women). We also investigated the impact of sex, age, cognitive status, and free-water fraction correction on these associations. Increased OSA severity was associated with larger hippocampal and entorhinal cortex volumes in women, but not in men. Greater OSA severity also correlated with increased hippocampal volumes in participants with amnestic mild cognitive impairment, but not in cognitively unimpaired participants, regardless of sex. Using free-water corrected volumes eliminated all significant associations with OSA severity. Therefore, the increase in medial temporal subregion volumes may possibly be due to edema. Whether these structural manifestations further progress to neuronal death in non-treated OSA patients should be investigated.

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YNIMG Journal 2020 Journal Article

TractoFlow: A robust, efficient and reproducible diffusion MRI pipeline leveraging Nextflow & Singularity

Guillaume Theaud
Jean-Christophe Houde
Arnaud Boré
François Rheault
Felix Morency
Maxime Descoteaux

Diffusion MRI tractography processing pipeline requires a large number of steps (typically 20+ steps). If parameters of these steps, number of threads, and random seed generators are not carefully controlled, the resulting tractography can easily be non-reproducible and non-replicable, even in test-test experiments. To handle these issues, we developed TractoFlow. TractoFlow is fully automatic from raw diffusion weighted images to tractography. The pipeline also outputs classical diffusion tensor imaging measures and several fiber orientation distribution function measures. TractoFlow supports the recent Brain Imaging Data Structure (BIDS) format as input and is based on two engines: Nextflow and Singularity. In this work, the TractoFlow pipeline is evaluated on three databases and shown to be efficient and reproducible from 98% to 100%, depending on parameter choices. Moreover, it is easy to use for non-technical users, with little to no installation requirements. TractoFlow is publicly available for academic research and is an important step forward for better structural brain connectivity mapping.

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YNIMG Journal 2018 Journal Article

Transient synchronization of hippocampo-striato-thalamo-cortical networks during sleep spindle oscillations induces motor memory consolidation

Arnaud Boutin
Basile Pinsard
Arnaud Boré
Julie Carrier
Stuart M. Fogel
Julien Doyon

Sleep benefits motor memory consolidation. This mnemonic process is thought to be mediated by thalamo-cortical spindle activity during NREM-stage2 sleep episodes as well as changes in striatal and hippocampal activity. However, direct experimental evidence supporting the contribution of such sleep-dependent physiological mechanisms to motor memory consolidation in humans is lacking. In the present study, we combined EEG and fMRI sleep recordings following practice of a motor sequence learning (MSL) task to determine whether spindle oscillations support sleep-dependent motor memory consolidation by transiently synchronizing and coordinating specialized cortical and subcortical networks. To that end, we conducted EEG source reconstruction on spindle epochs in both cortical and subcortical regions using novel deep-source localization techniques. Coherence-based metrics were adopted to estimate functional connectivity between cortical and subcortical structures over specific frequency bands. Our findings not only confirm the critical and functional role of NREM-stage2 sleep spindles in motor skill consolidation, but provide first-time evidence that spindle oscillations [11–17 Hz] may be involved in sleep-dependent motor memory consolidation by locally reactivating and functionally binding specific task-relevant cortical and subcortical regions within networks including the hippocampus, putamen, thalamus and motor-related cortical regions.

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