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Anuj Srivastava

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3 papers
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3

YNIMG Journal 2018 Journal Article

Mapping population-based structural connectomes

  • Zhengwu Zhang
  • Maxime Descoteaux
  • Jingwen Zhang
  • Gabriel Girard
  • Maxime Chamberland
  • David Dunson
  • Anuj Srivastava
  • Hongtu Zhu

Advances in understanding the structural connectomes of human brain require improved approaches for the construction, comparison and integration of high-dimensional whole-brain tractography data from a large number of individuals. This article develops a population-based structural connectome (PSC) mapping framework to address these challenges. PSC simultaneously characterizes a large number of white matter bundles within and across different subjects by registering different subjects’ brains based on coarse cortical parcellations, compressing the bundles of each connection, and extracting novel connection weights. A robust tractography algorithm and streamline post-processing techniques, including dilation of gray matter regions, streamline cutting, and outlier streamline removal are applied to improve the robustness of the extracted structural connectomes. The developed PSC framework can be used to reproducibly extract binary networks, weighted networks and streamline-based brain connectomes. We apply the PSC to Human Connectome Project data to illustrate its application in characterizing normal variations and heritability of structural connectomes in healthy subjects.

NeurIPS Conference 2011 Conference Paper

Signal Estimation Under Random Time-Warpings and Nonlinear Signal Alignment

  • Sebastian Kurtek
  • Anuj Srivastava
  • Wei Wu

While signal estimation under random amplitudes, phase shifts, and additive noise is studied frequently, the problem of estimating a deterministic signal under random time-warpings has been relatively unexplored. We present a novel framework for estimating the unknown signal that utilizes the action of the warping group to form an equivalence relation between signals. First, we derive an estimator for the equivalence class of the unknown signal using the notion of Karcher mean on the quotient space of equivalence classes. This step requires the use of Fisher-Rao Riemannian metric and a square-root representation of signals to enable computations of distances and means under this metric. Then, we define a notion of the center of a class and show that the center of the estimated class is a consistent estimator of the underlying unknown signal. This estimation algorithm has many applications: (1)registration/alignment of functional data, (2) separation of phase/amplitude components of functional data, (3) joint demodulation and carrier estimation, and (4) sparse modeling of functional data. Here we demonstrate only (1) and (2): Given signals are temporally aligned using nonlinear warpings and, thus, separated into their phase and amplitude components. The proposed method for signal alignment is shown to have state of the art performance using Berkeley growth, handwritten signatures, and neuroscience spike train data.

NeurIPS Conference 2003 Conference Paper

Geometric Analysis of Constrained Curves

  • Anuj Srivastava
  • Washington Mio
  • Xiuwen Liu
  • Eric Klassen

We present a geometric approach to statistical shape analysis of closed curves in images. The basic idea is to specify a space of closed curves satisfying given constraints, and exploit the differential geometry of this space to solve optimization and inference problems. We demonstrate this approach by: (i) defining and computing statistics of observed shapes, (ii) defining and learning a parametric probability model on shape space, and (iii) designing a binary hypothesis test on this space.

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