EAAI Journal 2026 Journal Article
An explainable fine-tuned transfer learning approach for multi-classification of skin cancer disease
- Ishwari Singh Rajput
- Anuj Kumar
- Jeewan Singh Koranga
- Megha Papola
- Tanuja Bisht
- Tanay Pratap Singh
Skin cancer is one of the most prevalent cancers in the world. Early detection remains challenging due to the visual similarities between lesion types and the low interpretability of deep learning models. This article presents an innovative approach for automatically classifying skin cancer through the combination of explainable artificial intelligence (XAI) and the concept of transfer learning using deep convolutional neural networks (CNNs). To improve visual clarity and contrast, the Human Against Machine with approximately 10, 000 training images (HAM10000) dataset is preprocessed using Denoising Autoencoder and Contrast Limited Adaptive Histogram Equalization (CLAHE). The proposed approach ensures accurate skin cancer diagnosis by utilizing highly advanced feature extraction capabilities of three pre-trained models Residual Network-50 (ResNet-50), Visual Geometry Group-16 (VGG16), and Inception-V3. A customized Deep Neural Network (DNN) classifier is then utilized to classify the fused extracted features into seven unique categories, including melanoma, basal cell carcinoma, and others. In addition, Local Interpretable Model-Agnostic Explanations (LIME) technique is used to give visual insights into model predictions to increase interpretability and promote confidence in the decision-making process. The proposed model outperformed individual pre-trained baseline models, with a classification accuracy of 95. 23%. A sensitivity analysis is also conducted to evaluate how different hyperparameters affect the performance of the model. The model achieved consistent precision and recall throughout the sensitivity analysis. This article presents the integration of deep learning and explainable artificial intelligence to produce reliable, transparent, and clinically useful diagnostic tools for the identification of skin cancer.