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Aditya Malusare

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TMLR Journal 2026 Journal Article

BalancedDPO: Adaptive Multi-Metric Alignment

  • Dipesh Tamboli
  • Souradip Chakraborty
  • Aditya Malusare
  • Biplab Banerjee
  • Amrit Singh Bedi
  • Vaneet Aggarwal

Diffusion models have achieved remarkable progress in text-to-image generation, yet aligning them with human preference remains challenging due to the presence of multiple, sometimes conflicting, evaluation metrics (e.g., semantic consistency, aesthetics, and human preference scores). Existing alignment methods typically optimize for a single metric or rely on scalarized reward aggregation, which can bias the model toward specific evaluation criteria. To address this challenge, we propose BalancedDPO, a framework that achieves multi-metric preference alignment within the Direct Preference Optimization (DPO) paradigm. Unlike prior DPO variants that rely on a single metric, BalancedDPO introduces a majority-vote consensus over multiple preference scorers and integrates it directly into the DPO training loop with dynamic reference model updates. This consensus-based formulation avoids reward- scale conflicts and ensures more stable gradient directions across heterogeneous metrics. Experiments on Pick-a-Pic, PartiPrompt, and HPD datasets demonstrate that BalancedDPO consistently improves preference win rates over the baselines across Stable Diffusion 1.5, Stable Diffusion 2.1 and SDXL backbones. Comprehensive ablations further validate the benefits of majority-vote aggregation and dynamic reference updating, highlighting the method's robustness and generalizability across diverse alignment settings.

NeurIPS Conference 2025 Conference Paper

GeneFlow: Translation of Single-cell Gene Expression to Histopathological Images via Rectified Flow

  • Mengbo Wang
  • Shourya Verma
  • Aditya Malusare
  • Luopin Wang
  • Yiyang Lu
  • Vaneet Aggarwal
  • Mario Sola
  • Ananth Grama

Spatial transcriptomics technologies can be used to align transcriptomes with histopathological morphology, presenting exciting new opportunities for biomolecular discovery. Using spatial transcriptomic gene expression and corresponding histology data, we construct a novel framework, GeneFlow, to map single- and multi-cell gene expression onto paired cellular images. By combining an attention-based RNA encoder with a conditional UNet guided by rectified flow, we generate high-resolution images with different staining methods (e. g. , H&E, DAPI) to highlight various cellular/ tissue structures. Rectified flow with high-order ODE solvers creates a continuous, bijective mapping between expression and image manifolds, addressing the many-to-one relationship inherent in this problem. Our method enables the generation of realistic cellular morphology features and spatially resolved intercellular interactions under genetic or chemical perturbations. This enables minimally invasive disease diagnosis by revealing dysregulated patterns in imaging phenotypes. Our rectified flow based method outperforms diffusion methods and baselines in all experiments. Code is available at https: //github. com/wangmengbo/GeneFlow.