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Abouzar Eslami

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4 papers
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4

AAAI Conference 2024 Conference Paper

Quantile-Based Maximum Likelihood Training for Outlier Detection

  • Masoud Taghikhah
  • Nishant Kumar
  • Siniša Šegvić
  • Abouzar Eslami
  • Stefan Gumhold

Discriminative learning effectively predicts true object class for image classification. However, it often results in false positives for outliers, posing critical concerns in applications like autonomous driving and video surveillance systems. Previous attempts to address this challenge involved training image classifiers through contrastive learning using actual outlier data or synthesizing outliers for self-supervised learning. Furthermore, unsupervised generative modeling of inliers in pixel space has shown limited success for outlier detection. In this work, we introduce a quantile-based maximum likelihood objective for learning the inlier distribution to improve the outlier separation during inference. Our approach fits a normalizing flow to pre-trained discriminative features and detects the outliers according to the evaluated log-likelihood. The experimental evaluation demonstrates the effectiveness of our method as it surpasses the performance of the state-of-the-art unsupervised methods for outlier detection. The results are also competitive compared with a recent self-supervised approach for outlier detection. Our work allows to reduce dependency on well-sampled negative training data, which is especially important for domains like medical diagnostics or remote sensing.

JBHI Journal 2020 Journal Article

Machine Learning Techniques for Ophthalmic Data Processing: A Review

  • Mhd Hasan Sarhan
  • M. Ali Nasseri
  • Daniel Zapp
  • Mathias Maier
  • Chris P. Lohmann
  • Nassir Navab
  • Abouzar Eslami

Machine learning and especially deep learning techniques are dominating medical image and data analysis. This article reviews machine learning approaches proposed for diagnosing ophthalmic diseases during the last four years. Three diseases are addressed in this survey, namely diabetic retinopathy, age-related macular degeneration, and glaucoma. The review covers over 60 publications and 25 public datasets and challenges related to the detection, grading, and lesion segmentation of the three considered diseases. Each section provides a summary of the public datasets and challenges related to each pathology and the current methods that have been applied to the problem. Furthermore, the recent machine learning approaches used for retinal vessels segmentation, and methods of retinal layers and fluid segmentation are reviewed. Two main imaging modalities are considered in this survey, namely color fundus imaging, and optical coherence tomography. Machine learning approaches that use eye measurements and visual field data for glaucoma detection are also included in the survey. Finally, the authors provide their views, expectations and the limitations of the future of these techniques in the clinical practice.

ICRA Conference 2019 Conference Paper

Needle Localization for Robot-assisted Subretinal Injection based on Deep Learning

  • Mingchuan Zhou
  • Xijia Wang
  • Jakob Weiss
  • Abouzar Eslami
  • Kai Huang 0001
  • Mathias Maier
  • Chris P. Lohmann
  • Nassir Navab

Subretinal injection is known to be a complicated task for ophthalmologists to perform, the main sources of difficulties are the fine anatomy of the retina, insufficient visual feedback, and high surgical precision. Image guided robot-assisted surgery is one of the promising solutions that bring significant surgical enhancement in treatment outcome and reduces the physical limitations of human surgeons. In this paper, we demonstrate a robust framework for needle detection and localization in subretinal injection using microscope-integrated Optical Coherence Tomography (MI-OCT) based on deep learning. The proposed method consists of two main steps: a) the preprocessing of OCT volumetric images; b) needle localization in the processed images. The first step is to coarsely localize the needle position based on the needle information above the retinal surface and crop the original image into a small region of interest (ROI). Afterward, the cropped small image is fed into a well trained network for detection and localization of the needle segment. The entire framework is extensively validated in ex-vivo pig eye experiments with robotic subretinal injection. The results show that the proposed method can localize the needle accurately with a confidence of 99. 2%.

ICRA Conference 2018 Conference Paper

Precision Needle Tip Localization Using Optical Coherence Tomography Images for Subretinal Injection

  • Mingchuan Zhou
  • Kai Huang 0001
  • Abouzar Eslami
  • Hessam Roodaki
  • Daniel Zapp
  • Mathias Maier
  • Chris P. Lohmann
  • Alois C. Knoll

Subretinal injection is a delicate and complex microsurgery, which requires surgeons to inject the therapeutic substance in a pre-operatively defined and intra-operatively updated subretinal target area. Due to the lack of subretinal visual feedback, it is hard to sense the insertion depth during the procedure, thus affecting the results of surgical outcome and hindering the widespread use of this treatment. This paper presents a novel approach to estimate the 3D position of the needle under the retina using the information from microscope-integrated Intraoperative Optical Coherence Tomography (iOCT). We evaluated our approach on both tissue phantom and ex-vivo porcine eyes. Evaluation results show that the average error in distance measurement is 4. 7 μm (maximum of 16. 5 μm). We furthermore, verified the feasibility of the proposed method to track the insertion depth of needle in robot-assisted subretinal injection.

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